Ophthalmology Unit, Department of Experimental, Diagnostic, and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Cornea. 2014 Sep;33(9):968-72. doi: 10.1097/ICO.0000000000000187.
The aim of this study was to assess corneal hysteresis (CH) and corneal resistance factor (CRF) in healthy subjects, to evaluate the relationship with age, and to investigate possible associations with other ocular factors.
Four hundred Italian subjects (male-to-female ratio, 168:232; mean age, 58.8 ± 17.2 years) were included and divided into 5 subgroups based on age. CH, CRF, and central corneal thickness (CCT) were measured by using the Ocular Response Analyzer and the integrated handheld pachymeter, and their relationship with gender, age, and ocular factors was evaluated.
The mean CH, CRF, and CCT values were 10 ± 1.6 mm Hg, 10.5 ± 1.7 mm Hg, and 532.2 μm, respectively. Women had a lower mean CH (9.9 vs. 10.2 mm Hg; P = 0.04) and CRF (10.3 vs. 10.8 mm Hg; P = 0.03) than did men. The youngest subjects had the highest CH (11.2 ± 1.5 mm Hg), whereas the oldest patients had the lowest CH values (9 ± 1.1 mm Hg). No significant differences in CRF were observed between age groups. CH and CRF showed a positive correlation (r = 0.58; P < 0.001), and both had a positive association with CCT (r = 0.27; P < 0.001 and r = 0.57; P < 0.001, respectively). The strongest correlations were observed between Goldmann-correlated intraocular pressure (IOP) and corneal-compensated IOP (r = 0.68; P < 0.001) and between Goldmann-correlated IOP and Goldmann applanation tonometry (r = 0.88; P < 0.001).
Gender and advancing age may influence corneal biomechanical properties. In our population, CH decreased with aging, and men demonstrated a higher CH and CRF than women did. Further, CH, CRF, and CCT were significantly related.
本研究旨在评估健康受试者的角膜滞后（CH）和角膜阻力因子（CRF），研究其与年龄的关系，并探讨与其他眼部因素的可能关联。
纳入 400 名意大利受试者（男/女比例为 168:232；平均年龄 58.8±17.2 岁），并根据年龄分为 5 个亚组。使用眼反应分析仪和集成手持眼压计测量 CH、CRF 和中央角膜厚度（CCT），评估其与性别、年龄和眼部因素的关系。
平均 CH、CRF 和 CCT 值分别为 10±1.6mmHg、10.5±1.7mmHg 和 532.2μm。女性的平均 CH（9.9 与 10.2mmHg；P=0.04）和 CRF（10.3 与 10.8mmHg；P=0.03）均低于男性。年龄最小的受试者 CH 最高（11.2±1.5mmHg），年龄最大的患者 CH 值最低（9±1.1mmHg）。不同年龄组之间 CRF 无显著差异。CH 和 CRF 呈正相关（r=0.58；P<0.001），两者均与 CCT 呈正相关（r=0.27；P<0.001 和 r=0.57；P<0.001）。Goldmann 相关眼压（IOP）与角膜补偿 IOP（r=0.68；P<0.001）和 Goldmann 压平眼压计与 Goldmann 压平眼压计（r=0.88；P<0.001）之间存在最强的相关性。
性别和年龄增长可能会影响角膜生物力学特性。在我们的人群中，CH 随年龄增长而降低，男性的 CH 和 CRF 高于女性。此外，CH、CRF 和 CCT 之间存在显著相关性。
