Department of Cornea and External Diseases, Advanced Eye Hospital and Institute, Navi Mumbai, India.
Cornea. 2014 Sep;33(9):910-3. doi: 10.1097/ICO.0000000000000188.
The aim of this study was to monitor corneal pachymetry changes during accelerated collagen cross-linking (CXL) for keratoconus while using isotonic riboflavin with HPMC.
All consecutive patients who underwent CXL for progressive keratoconus, using accelerated protocol and isotonic riboflavin with HPMC, from December 2012 to September 2013 were included in the study. The corneal pachymetry measurements were obtained at different time points: after epithelial removal, after riboflavin application for 20 minutes, and after ultraviolet A irradiation for 10 minutes at 9 mW/cm.
A total of 14 eyes of 14 consecutive patients were included in this study. The mean age of the patients was 19 ± 8 years. There were 8 left eyes and 6 right eyes. After epithelial debridement, the thinnest pachymetric readings were between 324 and 452 μm (average, 401.4 ± 40.7 μm). No significant difference (P = 0.80) was found between the deepithelialized corneal thickness and after 20 minutes of isotonic riboflavin with HPMC (pachymetric average, 405.3 ± 37.5 μm). Pachymetric average after ultraviolet A irradiation was 419.29 ± 20.60 μm. There was no statistical significant change in the corneal thickness after the irradiation (P = 0.24).
During corneal CXL using isotonic riboflavin and HPMC with accelerated cross-linking protocol, no significant decline in the corneal thickness was demonstrated.
本研究旨在监测使用等渗核黄素和 HPMC 的角膜交联（CXL）治疗圆锥角膜时角膜厚度的变化。
纳入 2012 年 12 月至 2013 年 9 月期间因进行性圆锥角膜使用加速方案和等渗核黄素加 HPMC 行 CXL 的所有连续患者。在不同时间点获得角膜厚度测量值：上皮去除后、核黄素应用 20 分钟后和紫外线 A 照射 10 分钟（9 mW/cm）后。
本研究共纳入 14 例 14 只眼连续患者。患者平均年龄为 19 ± 8 岁。左眼 8 只，右眼 6 只。上皮清创后，最薄的角膜厚度读数在 324 和 452 μm 之间（平均为 401.4 ± 40.7 μm）。去上皮化角膜厚度与应用 20 分钟等渗核黄素加 HPMC 后（角膜厚度平均为 405.3 ± 37.5 μm）之间无显著差异（P = 0.80）。紫外线 A 照射后的角膜厚度平均值为 419.29 ± 20.60 μm。照射后角膜厚度无统计学显著变化（P = 0.24）。
使用等渗核黄素和 HPMC 以及加速交联方案进行角膜 CXL 时，角膜厚度无明显下降。
