Bourdiec Amélie, Akoum Ali
Endocrinologie de la reproduction, centre de recherche hôpital Saint-François d'Assise, centre hospitalier universitaire de Québec, faculté de médecine, université Laval, Québec, Canada.
Med Sci (Paris). 2014 Jun-Jul;30(6-7):644-50. doi: 10.1051/medsci/20143006014. Epub 2014 Jul 11.
Endometrial receptivity to embryo implantation is one of the fundamental features of reproduction. Success of natural or assisted embryo implantation is low (20-25%). Implantation remains the result of a successful collaboration, tightly regulated and closely coordinated, between maternal and embryonic tissues located at the crossroads of endocrinology and immunology. In scientific terms, this collaboration is a mystery of human reproduction. The implanted blastocyst within the endometrium is dependent on a fine-tuned synchronization. Therefore, an accurate dialogue between the mother and the embryo is timely required to orchestrate mutual and well-synchronized changes in the developing embryo and maternal responsiveness in order to achieve a successful implantation. Maternal-derived mediators, such as steroid hormones, matrix-degrading enzymes, integrins, cytokines, chemokines, and many embryonic growth factors could be involved in the feto-maternal dialogue. Therefore, what is the maternal molecular signature compatible with embryo implantation?
子宫内膜对胚胎着床的接受性是生殖的基本特征之一。自然或辅助胚胎着床的成功率较低（20%-25%）。着床仍然是位于内分泌学和免疫学交叉点的母体组织与胚胎组织之间成功协作的结果，这种协作受到严格调控且密切协调。从科学角度来看，这种协作是人类生殖的一个谜团。子宫内膜内着床的囊胚依赖于精确的同步。因此，母亲与胚胎之间需要进行准确的对话，以便精心安排发育中胚胎的相互且同步良好的变化以及母体的反应，从而实现成功着床。母体来源的介质，如类固醇激素、基质降解酶、整合素、细胞因子、趋化因子和许多胚胎生长因子，可能参与了母胎对话。那么，与胚胎着床相容的母体分子特征是什么呢？
