Rodríguez-García José Antonio, Vázquez Lourdes, Ramos Fernando, Cuevas Beatriz, Martín Alejandro, Smucler Alicia, Guerola Dulce Nombre, Cantalapiedra Alberto, Alonso José María, Fernández Silvia, Díez Eva, Rodríguez María Jesús, Calmuntia María José, Aguilar Carlos, Sierra Magdalena, Gracia José Antonio, Cebeira María José, Cantalejo Rosa
Servicio de Hematología, Complejo Asistencial Universitario de León, León, España.
Servicio de Hematología, Complejo Asistencial Universitario de Salamanca, Salamanca, España.
Med Clin (Barc). 2015 Jun 8;144(11):491-500. doi: 10.1016/j.medcli.2014.03.037. Epub 2014 Jul 9.
We aimed to assess the incidence of haematological neoplasms (HNs) in Castilla y León (2,5 million inhabitants) and its distribution by age, gender and histological type.
The epidemiological profile based on the described variables of the 10,943 HNs diagnosed during a 10-years period was analyzed, compared with other studies.
The overall age-adjusted incidence was 29.4 cases/10(5) inhabitants-year, with some geographical differences. The mean age was 67.3 years, with a turning point between the 6th-7th decades of life from which there was a very significant increase of incidence. Two relevant facts where simultaneous with advancing age: decreased lymphoid neoplasms incidence and increased low degree neoplasms incidence. Lymphoid low degree neoplasms accounted for half of the registered processes, showed the greatest preference for male and reached the mode before the rest of neoplasms. Myeloid neoplasms incidence (9.5) was higher than that reported in other European registries, specially compared to southern European countries, opposite to lymphoid neoplasms incidence (20.0).
A higher myeloid neoplasms incidence and lower lymphoid one than expected was observed. The turning point of incidence is between the 6th-7th decades of life, with a preference for male that decreases with age. There is an increased incidence of HNs in the area where a higher density of potentially polluting facilities is concentrated.
我们旨在评估卡斯蒂利亚-莱昂地区(250万居民)血液系统肿瘤(HNs)的发病率及其按年龄、性别和组织学类型的分布情况。
分析了基于10年间诊断出的10943例血液系统肿瘤的上述变量的流行病学特征,并与其他研究进行了比较。
总体年龄调整发病率为29.4例/10⁵居民年,存在一些地理差异。平均年龄为67.3岁,在60至70岁之间出现转折点,此后发病率显著上升。随着年龄增长出现两个相关情况:淋巴系统肿瘤发病率下降,低度肿瘤发病率上升。低度淋巴系统肿瘤占登记病例的一半,最常见于男性,且比其他肿瘤更早达到发病高峰。髓系肿瘤发病率(9.5)高于其他欧洲登记处报告的发病率,特别是与南欧国家相比,与淋巴系统肿瘤发病率(20.0)相反。
观察到髓系肿瘤发病率高于预期,淋巴系统肿瘤发病率低于预期。发病转折点在60至70岁之间,男性更为常见,且随年龄增长而降低。在潜在污染设施密度较高的地区,血液系统肿瘤发病率有所上升。