Troussard X, Duchenet V, Cornet E, Mouchel D, Malet M, Collignon A
Registre régional des hémopathies malignes de Basse-Normandie (RRHMBN), France.
Rev Epidemiol Sante Publique. 2009 Jun;57(3):151-8. doi: 10.1016/j.respe.2009.02.204. Epub 2009 Apr 17.
The study was designed to present the incidence of all the haematological malignancies in Basse-Normandie over the period 1997-2004. We extracted the data from the "Registre régional des hémopathies malignes de Basse-Normandie (RRHMBN)", a French registry which belongs to the Association of the French Cancer Registries (FRANCIM). All the malignant haematological diseases were coded using the third edition of the International Classification for Oncologic Diseases (ICD-O-3) and the ADICAP classification, a special version adapted in 2001 for haematology. Five thousand five hundred and ten new cases of malignant haematological disorders were registered over the period 1997-2004. Whatever the department constituting the Basse-Normandie (Calvados, Manche and Orne), no significant difference of incidence was detected. In men, the more frequent malignant disorders were non-Hodgkin's malignant lymphomas (NHML) followed by chronic lymphocytic leukemia and other mature neoplasms, myelodysplastic syndromes (MDS), multiple myeloma (MM), myeloproliferative disorders (MPD), acute myeloid leukemias (AML), Hodgkin's lymphomas (HL), Waldenström's macroglobulinemia (WM) and acute lymphoblastic leukemia (ALL). In women, MM is the third more frequent haematological disorders after NHML and lymphocytic leukaemia and other mature neoplasms, MPD, MDS, AML, Hodgkin's lymphomas, WM and ALL. The other haematological disorders are very rare. We provide the incidence for the main haematological disorders and for the first time we also present the incidence of the different subtypes of the Hodgkin's and non-Hodgkin's malignant lymphomas, mature lymphoid neoplasms, MPD and also MDS. These results are useful for the organization and follow-up of medical care. The development of specialized haematology and active protocols can optimize the management of the older patients. A high quality of the collected data remains necessary for a continuous watching and research on patients with malignant haematological diseases.
该研究旨在呈现1997年至2004年期间下诺曼底地区所有血液系统恶性肿瘤的发病率。我们从“下诺曼底地区恶性血液病登记处（RRHMBN）”提取数据，该登记处是一个法国登记机构，隶属于法国癌症登记协会（FRANCIM）。所有恶性血液病均使用《国际肿瘤疾病分类》第三版（ICD - O - 3）以及2001年专门为血液学改编的ADICAP分类进行编码。1997年至2004年期间共登记了5510例恶性血液病新病例。在下诺曼底地区的各个省份（卡尔瓦多斯省、芒什省和奥恩省），未检测到发病率有显著差异。在男性中，较常见的恶性疾病是非霍奇金恶性淋巴瘤（NHML），其次是慢性淋巴细胞白血病和其他成熟肿瘤、骨髓增生异常综合征（MDS）、多发性骨髓瘤（MM）、骨髓增殖性疾病（MPD）、急性髓系白血病（AML）、霍奇金淋巴瘤（HL）、华氏巨球蛋白血症（WM）和急性淋巴细胞白血病（ALL）。在女性中，MM是继NHML和淋巴细胞白血病及其他成熟肿瘤、MPD、MDS、AML、霍奇金淋巴瘤、WM和ALL之后第三常见的血液系统疾病。其他血液系统疾病非常罕见。我们提供了主要血液系统疾病的发病率，并且首次呈现了霍奇金和非霍奇金恶性淋巴瘤、成熟淋巴样肿瘤、MPD以及MDS不同亚型的发病率。这些结果对医疗护理的组织和随访很有用。专业血液学的发展和积极的治疗方案可以优化老年患者的管理。对于持续监测和研究恶性血液病患者而言，高质量的收集数据仍然是必要的。
