Rauf Abdur, Uddin Ghias, Khan Haroon
Institute of Chemical Sciences, University of Peshawar, Peshawar, KPK, Pakistan.
Gandhara College of Pharmacy, Gandhara University, Peshawar, KPK, Pakistan.
Pak J Pharm Sci. 2014 Jul;27(4):855-8.
To explore the free radical scavenging properties of crude ethanolic extract of galls, bark, leaves, roots of Pistacia integerrima and its subsequent solvent fractions viz., n-hexane, chloroform, ethyl acetate and methanol against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) stable. In vitro DPPH based free radical was employed using querceitin as standard antioxidant while methanol as negative control. Different parts of P. integerrima showed marked scavenging on DPPH in a concentration dependent manner. The ethanolic extract exhibited 60.51 88.51% scavenging effect on DPPH which differentiated upon fractionation. of the part used, leaves of the plant were the least effective while n-hexane was the least dominant fraction. However, the rest of the parts and fractions demonstrated profound scavenging potential. This in-vitro study revealed an outstanding free radical scavenging potential of various solvent fractions of different parts of whole plant P. integerrima.
为探究笃耨香全株的没食子、树皮、树叶、树根的乙醇粗提物及其后续的溶剂萃取物（正己烷、氯仿、乙酸乙酯和甲醇）对1,1-二苯基-2-苦基肼（DPPH）自由基的清除特性。以槲皮素作为标准抗氧化剂，甲醇作为阴性对照，采用体外基于DPPH的自由基清除实验。笃耨香的不同部位对DPPH自由基的清除能力呈现出显著的浓度依赖性。乙醇提取物对DPPH自由基的清除率为60.51%至88.51%，各萃取物的清除效果有所差异。在所使用的部位中，树叶的清除效果最差，而正己烷萃取物的清除能力最弱。然而，其余部位和萃取物均表现出较强的自由基清除潜力。这项体外研究揭示了笃耨香全株不同部位的各种溶剂萃取物具有出色的自由基清除潜力。
