Lehrer S, O'Shaughnessy J, Song H K, Levine E, Savoretti P, Dalton J, Lipsztein R, Kalnicki S, Bloomer W D
Mt Sinai J Med. 1989 Mar;56(2):83-5.
Because there is elevation of pp60c-src activity in breast carcinoma tissue, we analyzed primary breast cancer tissue samples from 30 women to determine whether pp60c-src activity correlated with specific clinical parameters. We found that tumors with a progesterone receptor had higher pp60c-src activity than tumors without such a receptor. But there was no association of pp60c-src activity with the presence of an estrogen receptor or of nodes, or with menopausal status or age. The function of pp60c-src in normal cells and in breast cancer is unknown, as is the significance of our finding of an association of elevated pp60c-src activity and the presence of progesterone receptors.
由于乳腺癌组织中pp60c-src活性升高，我们分析了30名女性的原发性乳腺癌组织样本，以确定pp60c-src活性是否与特定临床参数相关。我们发现，具有孕激素受体的肿瘤比没有这种受体的肿瘤具有更高的pp60c-src活性。但pp60c-src活性与雌激素受体的存在、淋巴结情况、绝经状态或年龄均无关联。pp60c-src在正常细胞和乳腺癌中的功能尚不清楚，我们发现pp60c-src活性升高与孕激素受体的存在之间存在关联，其意义也不明确。
