Shen Szu-Yu, Huang Shih-Yi, Hsieh Ching-Hung, Hsu Ming-I, Cheng Chih-Yu, Hsu Chun-Sen
Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
School of Nutrition and Health Sciences, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
Taiwan J Obstet Gynecol. 2014 Jun;53(2):178-82. doi: 10.1016/j.tjog.2014.04.009.
Menstrual irregularity is one of the major complaints in women of reproductive age. The aim of this study was to evaluate the complications in women with different menstrual disturbances.
This is a retrospective study. A total of 576 women were screened first, and 470 women were included later [257 women with oligo/amenorrhea (149 hyperandrogenic and 108 nonhyperandrogenic women) and 213 normocyclic controls]. Endocrine and metabolic parameters and insulin resistance were compared among different menstrual patterns.
The average duration of menstrual cycle length was positively correlated with age, levels of androgens and prolactin, lipid profiles, and the parameters of insulin resistance. Hyperandrogenic women with amenorrhea had higher levels of androgens and more lipid profiles disorders than hyperandrogenic women with oligomenorrhea. However, nonhyperandrogenic women with amenorrhea had a degree of insulin resistance and metabolic disturbance similar to that of nonhyperandrogenic women with oligomenorrhea. Interestingly, for women with normal prolactin levels, serum prolactin levels were significantly lower in amenorrhea than oligomenorrhea in both hyperandrogenic and nonhyperandrogenic groups.
The degree of menstrual disturbances does not correlate with the severity of insulin resistance and metabolic disturbances in women without excess levels of androgen. For women with normal prolactin levels, amenorrheic patients had significantly lower serum prolactin levels than oligomenorrheic patients.
月经不调是育龄期女性的主要主诉之一。本研究旨在评估不同月经紊乱女性的并发症情况。
这是一项回顾性研究。首先对576名女性进行筛查，随后纳入470名女性[257名患有少经/闭经的女性（149名高雄激素血症女性和108名非高雄激素血症女性）以及213名月经周期正常的对照者]。比较不同月经模式下的内分泌和代谢参数以及胰岛素抵抗情况。
月经周期长度的平均持续时间与年龄、雄激素和催乳素水平、血脂谱以及胰岛素抵抗参数呈正相关。闭经的高雄激素血症女性比少经的高雄激素血症女性具有更高的雄激素水平和更多的血脂谱紊乱。然而，闭经的非高雄激素血症女性的胰岛素抵抗和代谢紊乱程度与少经的非高雄激素血症女性相似。有趣的是，对于催乳素水平正常的女性，在高雄激素血症和非高雄激素血症组中，闭经患者的血清催乳素水平均显著低于少经患者。
在没有雄激素水平过高的女性中，月经紊乱程度与胰岛素抵抗和代谢紊乱的严重程度无关。对于催乳素水平正常的女性，闭经患者的血清催乳素水平显著低于少经患者。
