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主动脉缩窄:使用支架植入的非手术治疗

Coarctation of the aorta: nonsurgical treatment using stent implantation.

作者信息

Ang H L, Lim C W, Hia C, Yip J, Quek S C

机构信息

Division of Cardiology, Department of Paediatrics, National University of Singapore, Lower Kent Ridge Road, Singapore. swee _chye

出版信息

Singapore Med J. 2014 Jun;55(6):302-4. doi: 10.11622/smedj.2014080.

DOI:10.11622/smedj.2014080
PMID:25017404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4294052/
Abstract

INTRODUCTION

Coarctation of the aorta (CoA) accounts for 5%-8% of all congenital heart defects. If left untreated, most patients with significant CoA will have varying degrees of morbidity (e.g. hypertension, stroke, collateral formation and ventricular hypertrophy), possibly even mortality. Traditionally, treatment for this condition is surgical. Herein, we report stenting during catheterisation as an alternative nonsurgical treatment option for patients with CoA, and present the treatment outcomes of patients who underwent this treatment option.

METHODS

We retrospectively reviewed four patients (2 men and 2 women; age range 20-41 years) who underwent CoA stenting under general anaesthesia for the treatment of native CoA or restenosis of CoA at our institution. Three patients had a 40-mm Palmaz stent inserted, while one had a 39-mm Cheatham-Platinum covered stent inserted. Angiography and measurement of pressure gradients were performed before and after stent implantation to ensure good treatment outcomes.

RESULTS

The patients' treatment outcomes were good, with a significant reduction in pressure gradients across the narrowed segments. Angiography showed relief of CoA. The patients were followed up for 1-3 years, during which no complications were noted.

CONCLUSION

This is the first reported series in Singapore on the nonsurgical treatment of CoAs in adult patients using stents during interventional cardiac catheterisation. This less invasive procedure may lead to a new paradigm shift with regard to the treatment of CoA.

摘要

引言

主动脉缩窄(CoA)占所有先天性心脏缺陷的5%-8%。如果不进行治疗,大多数患有严重CoA的患者会出现不同程度的发病情况(如高血压、中风、侧支形成和心室肥大),甚至可能死亡。传统上,这种疾病的治疗方法是手术治疗。在此,我们报告在导管插入术期间进行支架置入作为CoA患者的一种替代性非手术治疗选择,并呈现接受该治疗选择的患者的治疗结果。

方法

我们回顾性分析了4例患者(2例男性和2例女性;年龄范围20-41岁),他们在我院接受全身麻醉下的CoA支架置入术,以治疗原发性CoA或CoA再狭窄。3例患者植入了40毫米的帕尔马兹支架,1例患者植入了39毫米的奇塔姆-铂覆膜支架。在支架植入前后进行血管造影和压力梯度测量,以确保良好的治疗效果。

结果

患者的治疗效果良好,狭窄段的压力梯度显著降低。血管造影显示CoA缓解。对患者进行了1-3年的随访,在此期间未发现并发症。

结论

这是新加坡首次报道的关于成年患者在介入性心导管插入术中使用支架对CoA进行非手术治疗的系列研究。这种侵入性较小的手术可能会导致CoA治疗方面的新范式转变。

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本文引用的文献

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Endovascular stenting for aortic (re)coarctation in adults.成人主动脉(再)狭窄的血管内支架置入术。
Neth Heart J. 2010 Sep;18(9):430-6. doi: 10.1007/BF03091810.
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Comparing balloon angioplasty, stenting and surgery in the treatment of aortic coarctation.比较球囊血管成形术、支架置入术和手术治疗主动脉缩窄的效果。
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Covered stents in the management of coarctation of the aorta in the adult: initial results and 1-year angiographic and hemodynamic follow-up.覆膜支架治疗成人主动脉缩窄:初步结果和 1 年的血管造影和血流动力学随访。
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Procedural results and acute complications in stenting native and recurrent coarctation of the aorta in patients over 4 years of age: a multi-institutional study.4岁以上患者主动脉缩窄原发及复发病变支架置入术的手术结果和急性并发症:一项多机构研究
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Acute and intermediate outcomes, and evaluation of injury to the aortic wall, as based on 15 years experience of implanting stents to treat aortic coarctation.基于15年主动脉缩窄支架植入经验的急性和中期结果以及主动脉壁损伤评估。
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