Roujeau Jean-Claude, Haddad Cynthia, Paulmann Maren, Mockenhaupt Maja
Université Paris-Est Créteil, France; RegiSCAR Network.
RegiSCAR Network; Reference Center for Blistering Diseases, Hôpital Henri Mondor, Créteil, France.
Immunol Allergy Clin North Am. 2014 Aug;34(3):473-87, vii. doi: 10.1016/j.iac.2014.04.012.
Nonimmediate hypersensitivity to drugs has a huge diversity of clinical presentations affecting exclusively or predominantly a single organ (most often the skin) or multiple organs. The latter is the rule with drug reaction with eosinophilia and systemic symptoms, and with drug-induced vasculitis. The management includes a dozen successive steps. Finally, the patient should be provided clear information on the suspected cause of the reaction, recommendations for follow-up after severe reactions associated with a risk of sequelae, and clear recommendations for future use of medications. Pharmacovigilance networks should be informed.
药物非速发型超敏反应有多种多样的临床表现，仅累及或主要累及单一器官（最常见的是皮肤）或多个器官。后者在伴有嗜酸性粒细胞增多和全身症状的药物反应以及药物性血管炎中较为常见。处理包括一系列连续的步骤。最后，应向患者提供关于反应疑似原因的明确信息、严重反应且伴有后遗症风险后的随访建议以及关于未来用药的明确建议。应向药物警戒网络通报情况。
