Tang An, Billiard Jean-Sébastien, Chagnon David-Olivier, Rizk Fadi, Olivié Damien, Turcotte Simon, Chagnon Miguel, Lepanto Luigi
Department of Radiology, Centre Hospitalier de l'Université de Montréal (CHUM), Hôpital Saint-Luc, 1058 Rue Saint-Denis, Montréal, Québec, Canada H2X 3J4; Research Center CHUM, Hôpital Saint-Luc, Montréal, Québec, Canada.
Department of Radiology, Centre Hospitalier de l'Université de Montréal (CHUM), Hôpital Saint-Luc, 1058 Rue Saint-Denis, Montréal, Québec, Canada H2X 3J4.
Acad Radiol. 2014 Aug;21(8):977-85. doi: 10.1016/j.acra.2014.04.004.
To assess the optimal pancreatic phase delay in terms of parenchymal enhancement and tumor-to-pancreas contrast with a bolus-tracking method.
Patients referred for suspicion of pancreatic tumor and undergoing 64-detector computed tomography scanner were randomized to an individualized scan delay of 10, 20, or 30 seconds of nonionic contrast material (370 mg I/mL) after aortic enhancement above 150 Hounsfield units. The volume of contrast was adjusted to patient weight. Pancreatic and tumor enhancements were measured. Statistical analysis included analysis of variance and post hoc Tukey tests.
One hundred and fifty patients were randomized to individualized scan delays of 10, 20, or 30 seconds. Pancreatic parenchymal enhancement in all patients (n = 150) was significantly higher with a delay of 20 or 30 seconds than that with 10 seconds (P < .001 for both). Tumor-to-pancreas contrast for solid tumors (n = 59) was significantly higher with a delay of 30 seconds than that with 10 seconds (P = .015). Adenocarcinoma-to-pancreas contrast during pancreatic phase was significantly higher for a 20- or 30-second delay than for a 10-second delay (P = .027 and .011, respectively) for one reader.
With a flow rate of 4 mL/s and weight-adjusted contrast volume, an individualized scan delay of 30 seconds after aortic transit time revealed higher pancreatic enhancement and tumor-to-pancreas contrast than that with a delay of 10 seconds.
采用团注追踪法评估在实质强化及肿瘤与胰腺对比方面的最佳胰腺期延迟。
因怀疑胰腺肿瘤而接受64层螺旋CT扫描的患者，在主动脉强化超过150亨氏单位后，随机给予10、20或30秒的非离子型对比剂（370 mg I/mL）个体化扫描延迟。对比剂用量根据患者体重进行调整。测量胰腺和肿瘤的强化情况。统计分析包括方差分析和事后Tukey检验。
150例患者被随机分为10、20或30秒的个体化扫描延迟组。所有患者（n = 150）在延迟20或30秒时的胰腺实质强化显著高于10秒时（两者P均<0.001）。实性肿瘤（n = 59）在延迟30秒时的肿瘤与胰腺对比显著高于10秒时（P = 0.015）。对于一名阅片者，在胰腺期腺癌与胰腺的对比在延迟20或30秒时显著高于10秒时（分别为P = 0.027和0.011）。
在流速为4 mL/s且对比剂用量根据体重调整的情况下，主动脉通过时间后30秒的个体化扫描延迟显示出比10秒延迟更高的胰腺强化及肿瘤与胰腺对比。
