Perucha Esperanza, Rebollo-Mesa Irene, Sagoo Pervinder, Hernandez-Fuentes Maria P
Section of Experimental Immunobiology, Division of Transplantation Immunology and Mucosal Biology, King's College London , London, UK ; Medical Research Centre for Transplantation, King's College London, Guy's Hospital , London, UK ; NIHR Biomedical Research Centre, Guy's and St Thomas' Hospital and King's College London , London, UK.
Medical Research Centre for Transplantation, King's College London, Guy's Hospital , London, UK.
Kidney Int Suppl (2011). 2011 Aug;1(2):40-46. doi: 10.1038/kisup.2011.11.
Induction of transplantation tolerance remains the ideal long-term clinical and logistic solution to the current challenges facing the management of renal allograft recipients. In this review, we describe the recent studies and advances made in identifying biomarkers of renal transplant tolerance, from study inceptions, to the lessons learned and their implications for current and future studies with the same goal. With the age of biomarker discovery entering a new dimension of high-throughput technologies, here we also review the current approaches, developments, and pitfalls faced in the subsequent statistical analysis required to identify valid biomarker candidates.
诱导移植耐受仍然是解决肾移植受者管理当前面临挑战的理想长期临床和后勤解决方案。在本综述中，我们描述了在确定肾移植耐受生物标志物方面的最新研究和进展，从研究起始，到所吸取的经验教训及其对当前和未来具有相同目标研究的启示。随着生物标志物发现时代进入高通量技术的新维度，在此我们还综述了在识别有效生物标志物候选物所需的后续统计分析中面临的当前方法、进展和陷阱。
