Jeffrey M, Low J C, Uggla A
Lasswade Veterinary Laboratory, Penicuik, Midlothian.
Vet Rec. 1989 Apr 22;124(16):422-6. doi: 10.1136/vr.124.16.422.
An outbreak of muscle disease affected approximately 20 of 600 ewes in spring 1987 in south-east Scotland. The clinical signs were a flaccid paralysis of the hind limbs and in severe cases collapse. Serum creatine kinase and aspartate aminotransferase activities were increased. Clinically affected sheep had a mean reciprocal serum antibody titre in a sarcocystis immunofluorescence antibody test of 557 whereas 22 sheep from the same flock, sampled one year earlier, showed a mean reciprocal titre of only 51. Histologically a heavy infestation of sarcocysts, myodegeneration and a non-suppurative myositis centred on degenerating sarcocysts were observed in a wide range of skeletal muscles and myocardium from four affected sheep. Monensin sodium had been inadvertently included in the protein pellet used in the feed for one week before the onset of the disease.
1987年春季，苏格兰东南部600只母羊中约有20只爆发了肌肉疾病。临床症状为后肢弛缓性麻痹，严重时会倒地。血清肌酸激酶和天冬氨酸转氨酶活性升高。在肉孢子虫免疫荧光抗体试验中，临床患病绵羊的血清抗体平均倒数滴度为557，而一年前从同一羊群中采样的22只绵羊的平均倒数滴度仅为51。组织学检查发现，在4只患病绵羊的多种骨骼肌和心肌中，观察到肉孢子虫大量寄生、肌细胞变性以及以变性肉孢子虫为中心的非化脓性肌炎。在疾病发作前一周，用于喂养的蛋白质颗粒中意外混入了莫能菌素钠。
