Ross R J, Savage M O, Kirk J M, Besser G M
Department of Endocrinology, St Bartholomew's Hospital, London, UK.
Acta Paediatr Scand Suppl. 1989;349:114-6; discussion 123-4. doi: 10.1111/j.1651-2227.1989.tb17181.x.
The development of a long-acting or depot preparation of growth hormone-releasing hormone (GHRH) may have many advantages over conventional treatment (with GH) of GH-deficient children. Pyridostigmine, an acetylcholinesterase inhibitor, has been shown to augment basal GH secretion and the GH response to GHRH in short children. It may thus provide adjuvant therapy to depot GHRH. The GH response to a nocturnal subcutaneous infusion of GHRH (1-29)NH2 in doses of 5 and 10 micrograms/kg/hour was investigated in five short, slowly growing children. The effect of oral pyridostigmine 60 mg on nocturnal GH secretion and the GH response to a nocturnal infusion was also examined. The subcutaneous infusion of GHRH augmented pulsatile GH release in all five children. There was a dose-related response to subcutaneous GHRH for the GH area under the curve and mean GH pulse amplitude, but no change in the number of pulses. There was a significant rise in the mean baseline GH concentration during the GHRH infusion compared with placebo. Pyridostigmine had no effect on either basal or stimulated GH secretion.
与采用生长激素（GH）对生长激素缺乏症儿童进行常规治疗相比，长效或储库型生长激素释放激素（GHRH）制剂的开发可能具有诸多优势。吡啶斯的明是一种乙酰胆碱酯酶抑制剂，已证实其可增强矮小儿童的基础GH分泌以及GH对GHRH的反应。因此，它可能为储库型GHRH提供辅助治疗。在5名身材矮小、生长缓慢的儿童中，研究了夜间皮下输注剂量为5和10微克/千克/小时的GHRH（1-29）NH2时的GH反应。还检查了口服60毫克吡啶斯的明对夜间GH分泌以及对夜间输注的GH反应的影响。皮下输注GHRH使所有5名儿童的GH呈脉冲式释放增加。对于曲线下GH面积和平均GH脉冲幅度，皮下GHRH存在剂量相关反应，但脉冲次数无变化。与安慰剂相比，在输注GHRH期间平均基线GH浓度显著升高。吡啶斯的明对基础或刺激的GH分泌均无影响。
