淀粉样β蛋白前体是一种促细胞分裂剂。
Amyloid beta protein precursor is a mitogen.
作者信息
Schubert D, Cole G, Saitoh T, Oltersdorf T
机构信息
Salk Institute for Biological Studies, San Diego, California 92138.
出版信息
Biochem Biophys Res Commun. 1989 Jul 14;162(1):83-8. doi: 10.1016/0006-291x(89)91965-7.
PMID:2502115
Abstract
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
摘要
含有蛋白酶抑制剂序列的分泌型淀粉样β蛋白前体形式对瑞士3T3细胞具有促有丝分裂作用，而缺乏蛋白酶抑制剂结构域的前体分子则没有。在蛋白浓度为8×10⁻⁹ M时，DNA合成受到十倍的刺激。
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