Bonfiglioli Rachele, Nanni Cristina, Martignani Cristian, Zanoni Lucia, La Donna Raffaele, Diemberger Igor, Boriani Giuseppe, Pettinato Cinzia, Sambuceti Gianmario, Fanti Stefano, Mansi Luigi
Nuclear Medicine Department, S. Orsola-Malpighi Hospital, Bologna, Italy.
Curr Radiopharm. 2014;7(2):79-83. doi: 10.2174/1874471007666140714111304.
Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases. Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation. We used (11)C-meta-hydroxy-ephedrine ((11)C-mHED), a catecholamine analogue, as a radiotracer usable with a PET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labeling with (11)C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showing the radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility of PET/CT with the radiolabeled catecholamine analogue ((11)C-mHED) in order to determine sympathetic innervation in the human heart.
心脏自主神经系统的改变在许多心脏病的发病过程中起着重要作用。核成像工具已被证明对心肌神经支配的整体和区域评估有用。我们使用（11）C-间羟基麻黄碱（（11）C-mHED），一种儿茶酚胺类似物，作为可与PET/CT扫描仪一起使用的放射性示踪剂来研究心脏交感神经系统。在快速自动合成mHED并将其用（11）C标记后，我们使用PET/CT扫描仪获取心脏图像。在本文中，我们展示了初步结果，显示了注射后10分钟放射性示踪剂在人体中的生物分布。本研究评估了使用放射性标记的儿茶酚胺类似物（（11）C-mHED）进行PET/CT以确定人类心脏交感神经支配的可行性。
