Kacalak-Rzepka Anna, Kiedrowicz Magdalena, Maleszka Romuald
Ann Acad Med Stetin. 2013;59(2):12-7.
Psoriasis is a chronic inflammatory dermatosis leading to the development of systemic inflammatory reaction. Previous data indicated the coexistence of psoriasis and the occurrence of metabolic disorders, with the common background of both processes determined by a chronic inflammation. The coexisting disorders, including type 2 diabetes, hypertension, heart ischemic disease, dislipidemia and obesity may have an important impact on intensity of psoriasis activity.
The analysis comprised of 82 randomly matched patients with various clinical forms of psoriasis, aged 17 to 81 years. In patients PASI and BSA indexes, BMI value and laboratory parameters of metabolic status (glucose and ureic acid levels, lipid fractions and CRP level in the serum) were evaluated.
An average age in examined group was 54,3 years, an average time of presence of psoriasis symptoms was approximately 20 years. An average PASI value was 21,4; an average BSA value was 39.7%. The coexistence of type 2 diabetes was found in 14.6% of patients, hypertension in 42.7% and heart ischemic disease in 17%. Particularly large group of examined patients comprised persons with overweight (34.1%) and obesity (30.5%). Positive correlation between BSA and body weight, BSA and BMI value, BSA and abdominal circumference as well as positive correlation between PASI and body weight, PASI and BMI value, PASI and abdominal circumference were observed. Abnormal serum glucose levels were observed in 19.5% persons, ureic acid level in 2.9%, total cholesterol in 37.8% LDL cholesterol in 48.8%, and HDL cholesterol in 46.3%. CRP level was elevated in 43.9% patients. Positive correlation between BSA and ureic acid level, as well as PASI and ureic acid level was estimated. No correlation between PASI and the other laboratory parameters was found.
The occurrence of metabolic syndrome is more common in patients with psoriasis in comparison to the general population. The extent and severity of psoriatic lesions correlate with high body weight, BMI and the level of ureic acid.
银屑病是一种慢性炎症性皮肤病，可导致全身炎症反应。先前的数据表明银屑病与代谢紊乱并存，这两个过程的共同背景是慢性炎症。并存的疾病，包括2型糖尿病、高血压、心脏缺血性疾病、血脂异常和肥胖，可能对银屑病活动强度产生重要影响。
分析包括82例年龄在17至81岁之间、患有各种临床类型银屑病的随机匹配患者。评估患者的银屑病面积和严重程度指数（PASI）、体表面积（BSA）指数、体重指数（BMI）值以及代谢状态的实验室参数（血清葡萄糖和尿酸水平、血脂成分和C反应蛋白水平）。
研究组的平均年龄为54.3岁，银屑病症状的平均出现时间约为20年。平均PASI值为21.4；平均BSA值为39.7%。14.6%的患者并存2型糖尿病，42.7%的患者并存高血压，17%的患者并存心脏缺血性疾病。接受检查的患者中特别大的一组是超重者（34.1%）和肥胖者（30.5%）。观察到BSA与体重、BSA与BMI值、BSA与腹围之间呈正相关，以及PASI与体重、PASI与BMI值、PASI与腹围之间呈正相关。19.5%的人血清葡萄糖水平异常，2.9%的人尿酸水平异常，37.8%的人总胆固醇异常，48.8%的人低密度脂蛋白胆固醇异常，46.3%的人高密度脂蛋白胆固醇异常。43.9%的患者C反应蛋白水平升高。估计BSA与尿酸水平以及PASI与尿酸水平之间呈正相关。未发现PASI与其他实验室参数之间存在相关性。
与普通人群相比，银屑病患者中代谢综合征的发生率更高。银屑病皮损的范围和严重程度与高体重、BMI和尿酸水平相关。
