子宫癌肉瘤患者术后化疗的评估：东北妇科癌症中心的一项回顾性调查
Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit.
作者信息
Otsuki Ai, Otsuki Takeo, Tokunaga Hideki, Niikura Hitoshi, Nagase Satoru, Sugiyama Takashi, Toyoshima Masafumi, Utsunomiya Hiroki, Yokoyama Yoshihito, Mizunuma Hideki, Sato Naoki, Terada Yukihiro, Shoji Tadahiro, Sugiyama Toru, Nakahara Kenji, Ohta Tsuyoshi, Yamada Hidekazu, Tase Toru, Nishiyama Hiroshi, Fujimori Keiya, Takano Tadao, Takahashi Fumiaki, Watanabe Yoh, Yaegashi Nobuo
机构信息
Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
出版信息
Int J Clin Oncol. 2015 Jun;20(3):574-8. doi: 10.1007/s10147-014-0732-0. Epub 2014 Jul 18.
BACKGROUND
The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma.
METHODS
We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit.
RESULTS
A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤ 50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period.
CONCLUSIONS
Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.
背景
本研究的目的是评估包括术后化疗疗效在内的日本子宫癌肉瘤患者的预后因素。
方法
我们对东北妇科癌症协作组的7家医疗机构进行了一项回顾性调查。
结果
共有45例行子宫切除术和双侧输卵管卵巢切除术的患者入组。根据患者年龄（≤50岁与>50岁）或腹膜后淋巴结清扫术（进行与未进行），总生存期未观察到显著差异。然而，在25个月的中位随访期内，国际妇产科联盟分期（Ⅰ/Ⅱ期与Ⅲ/Ⅳ期）和术后化疗（接受与未接受）在单因素和多因素分析中均为显著的预后因素。
结论
我们的结果表明，日本子宫癌肉瘤各期患者均应考虑术后化疗。
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