Lee Su Young, Shin Aesun, Kim Byung Chang, Lee Jeong Hee, Han Kyung Su, Hong Chang Won, Sohn Dae Kyung, Park Sung Chan, Chang Hee Jin, Oh Jae Hwan
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.
Cancer Epidemiol. 2014 Oct;38(5):623-7. doi: 10.1016/j.canep.2014.06.005. Epub 2014 Jul 14.
We assessed the association between a family history of malignancy and risk of colorectal adenoma among individuals aged 40-49 years.
The study population consisted of subjects, aged in their 40s, who underwent colonoscopy. Their family histories of cancer were collected with a self-administered questionnaire. A logistic regression model was used to assess the association between a family history of cancer and the risk of colorectal polyp.
In total, 2275 participants were included in the study. Univariate analysis showed that old age, male sex, current cigarette smoking, BMI>25 kg/m(2), and a family history of colorectal cancer (CRC) were risk factors for the development of sporadic colorectal adenomatous polyps in these patients. A multivariate analysis showed that a family history of CRC or kidney cancer was associated with adenoma development. A family history of CRC was also a risk factor for advanced and multiple adenoma.
This study shows that a family history of CRC is a risk factor for advanced and multiple colorectal adenoma in people in their 40s. These results support earlier screening for colorectal neoplasms in individuals with a family history of CRC.
我们评估了40至49岁个体的恶性肿瘤家族史与结直肠腺瘤风险之间的关联。
研究人群包括40多岁接受结肠镜检查的受试者。通过自行填写的问卷收集他们的癌症家族史。采用逻辑回归模型评估癌症家族史与结直肠息肉风险之间的关联。
该研究共纳入2275名参与者。单因素分析显示，年龄较大、男性、当前吸烟、BMI>25 kg/m²以及结直肠癌（CRC）家族史是这些患者发生散发性结直肠腺瘤性息肉的危险因素。多因素分析显示，CRC或肾癌家族史与腺瘤发生有关。CRC家族史也是高级别和多发性腺瘤的危险因素。
本研究表明，CRC家族史是40多岁人群发生高级别和多发性结直肠腺瘤的危险因素。这些结果支持对有CRC家族史的个体进行更早的结直肠肿瘤筛查。
