40岁左右亲属的恶性肿瘤家族史与大肠腺瘤性息肉之间的关联

Association between family history of malignant neoplasm with colorectal adenomatous polyp in 40s aged relative person.

作者信息

Lee Su Young, Shin Aesun, Kim Byung Chang, Lee Jeong Hee, Han Kyung Su, Hong Chang Won, Sohn Dae Kyung, Park Sung Chan, Chang Hee Jin, Oh Jae Hwan

机构信息

Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.

Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea.

出版信息

Cancer Epidemiol. 2014 Oct;38(5):623-7. doi: 10.1016/j.canep.2014.06.005. Epub 2014 Jul 14.

DOI:10.1016/j.canep.2014.06.005

PMID:25035156

Abstract

PURPOSE

We assessed the association between a family history of malignancy and risk of colorectal adenoma among individuals aged 40-49 years.

METHODS

The study population consisted of subjects, aged in their 40s, who underwent colonoscopy. Their family histories of cancer were collected with a self-administered questionnaire. A logistic regression model was used to assess the association between a family history of cancer and the risk of colorectal polyp.

RESULTS

In total, 2275 participants were included in the study. Univariate analysis showed that old age, male sex, current cigarette smoking, BMI>25 kg/m(2), and a family history of colorectal cancer (CRC) were risk factors for the development of sporadic colorectal adenomatous polyps in these patients. A multivariate analysis showed that a family history of CRC or kidney cancer was associated with adenoma development. A family history of CRC was also a risk factor for advanced and multiple adenoma.

CONCLUSIONS

This study shows that a family history of CRC is a risk factor for advanced and multiple colorectal adenoma in people in their 40s. These results support earlier screening for colorectal neoplasms in individuals with a family history of CRC.

摘要