Bhamra-Ariza Paul, Muller David W M
Cardiology Dept, St Vincent's Hospital, Victoria St, Darlinghurst, NSW 2010, Australia.
Cardiology Dept, St Vincent's Hospital, Victoria St, Darlinghurst, NSW 2010, Australia.
Heart Lung Circ. 2014 Nov;23(11):1009-19. doi: 10.1016/j.hlc.2014.05.021. Epub 2014 Jun 26.
Mitral regurgitation is the most common valve abnormality worldwide and its prevalence is expected to increase in the future due to aging of the population. Percutaneous mitral valve repair therapies may offer an opportunity to treat severe MR in the elderly or other high-risk groups who would otherwise be ineligible for surgery. The MitraClip system uses edge-to-edge coaptation of the mitral leaflets to create a double-orifice valve and reduce MR. It has been performed in over 10 000 patients to date, and as experience has improved, procedural times have shortened from over 200 minutes to less than 100 minutes, with increasing numbers of patients being left with ≤ grade 2+ MR. This review will focus on the literature available on MitraClip and other novel percutaneous techniques that are being developed for the treatment of severe MR.
二尖瓣反流是全球最常见的瓣膜异常，由于人口老龄化，预计其患病率在未来还会增加。经皮二尖瓣修复疗法可能为治疗老年或其他高风险组别的严重二尖瓣反流提供机会，否则这些患者将不符合手术条件。MitraClip系统利用二尖瓣叶的边缘对边缘贴合来创建双孔瓣膜并减少二尖瓣反流。迄今为止，该手术已在超过10000名患者中实施，随着经验的积累，手术时间已从超过200分钟缩短至不到100分钟，二尖瓣反流≤2+级的患者数量也在增加。本综述将聚焦于有关MitraClip以及正在研发用于治疗严重二尖瓣反流的其他新型经皮技术的现有文献。
