Bassiri-Jahromi Shahindokht
Department of Medical Mycology, Pasteur Institute of Iran, Tehran, Iran.
Indian J Dermatol Venereol Leprol. 2014 Jul-Aug;80(4):331-4. doi: 10.4103/0378-6323.136903.
Paecilomyces is a genus of saprophytic fungus that has been associated, in rare instances, with human disease. We report two cases in which Paecilomyces lilacinus was isolated from cutaneous and subcutaneous lesions in an immunocompromised and an immunocompetent host. The first case was a subcutaneous infection due to P. lilacinus in a patient with a renal transplant and diabetes mellitus. The second case was an immunocompetent young woman who developed a cutaneous infection, with no identified predisposing factors. A biopsy from each patient provided an initial diagnosis of fungal elements in the tissues under examination and multiple positive fungal cultures were obtained from the tissue biopsy samples. Both microscopic and macroscopic examinations of the biopsy revealed the presence of P. lilacinus. Each of the two cases was successfully treated with oral ketoconazole (200 mg/day) and itraconazole. We also review previously reported cases in which the clinical history and response to therapy were noted.
拟青霉是一种腐生真菌属，在极少数情况下与人类疾病有关。我们报告了两例从免疫功能低下和免疫功能正常宿主的皮肤及皮下病变中分离出淡紫拟青霉的病例。第一例是一名患有肾移植和糖尿病的患者发生的由淡紫拟青霉引起的皮下感染。第二例是一名免疫功能正常的年轻女性，她患上了皮肤感染，未发现诱发因素。对每位患者的活检初步诊断为检查的组织中有真菌成分，并且从组织活检样本中获得了多次阳性真菌培养结果。活检的显微镜和肉眼检查均显示存在淡紫拟青霉。这两例患者均通过口服酮康唑（200毫克/天）和伊曲康唑成功治愈。我们还回顾了先前报告的记录有临床病史和治疗反应的病例。
