Başkent University Faculty of Medicine, Department of Hematology, İstanbul, Turkey.
Başkent University Faculty of Medicine, Department of Hematology, Ankara, Turkey.
Turk J Haematol. 2014 Jun;31(2):121-7. doi: 10.4274/tjh.2012.0150. Epub 2014 Jun 10.
Venous, arterial, and microcirculatory events are frequently encountered in the clinical course of essential thrombocytosis and polycythemia vera. We aimed to investigate the levels of soluble endothelial protein C receptor (sEPCR) in myeloproliferative diseases to see whether there was a difference between the patients with and without history of thromboembolism.
The study included patients with polycythemia vera (n=12), patients with essential thrombocytosis (n=13), and controls (n=29). In all groups, we measured proteins C and S, antithrombin and sEPCR levels, and plasma concentrations of thrombin-antithrombin complex, prothrombin fragments 1+2, and D-dimer.
Comparing the patients with and without history of thromboembolic attack, statistically significant differences were not observed in terms of sEPCR, D-dimer, thrombin-antithrombin complex, prothrombin fragments 1+2, and hematocrit levels (p=0.318, 0.722, 0.743, 0.324, and 0.065, respectively).
Significant increase in the parameters that reflect activation of coagulation, such as sEPCR, thrombin-antithrombin complex, prothrombin fragments 1+2, and D-dimer, reflects the presence of a basal condition that leads to a tendency toward thrombosis development in ET and PV when compared to healthy controls.
静脉、动脉和微循环事件在原发性血小板增多症和真性红细胞增多症的临床过程中经常发生。我们旨在研究骨髓增殖性疾病中可溶性内皮蛋白 C 受体（sEPCR）的水平，以观察有无血栓栓塞史的患者之间是否存在差异。
该研究包括真性红细胞增多症患者（n=12）、原发性血小板增多症患者（n=13）和对照组（n=29）。在所有组中，我们测量了蛋白 C 和 S、抗凝血酶和 sEPCR 水平，以及血浆凝血酶-抗凝血酶复合物、凝血酶原片段 1+2 和 D-二聚体浓度。
比较有和无血栓栓塞史的患者，sEPCR、D-二聚体、凝血酶-抗凝血酶复合物、凝血酶原片段 1+2 和红细胞压积水平无统计学差异（p=0.318、0.722、0.743、0.324 和 0.065）。
与健康对照组相比，sEPCR、凝血酶-抗凝血酶复合物、凝血酶原片段 1+2 和 D-二聚体等反映凝血激活的参数显著增加，表明 ET 和 PV 存在导致血栓形成倾向的基础状态。
