Tsygankov B D, Agasarain E G, Zykova A S
Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(5):86-91.
The effect of antipsychotic drugs, typical and atypical neuroleptics, is described in the following sections of this paper: antipsychotic drugs and carbohydrate metabolism, prevention and risk factors, pharmacoepidemiology, treatment. It is concluded that neuroleptic treatment increases the risk of metabolic impairment. Mechanisms of this effect are not clear so far. Ethnicity, sex, age and features of the therapy may play a role. Clozapine, olanzapine, ziprasidone, sertindole and some typical neuroleptics are risk factors as well. Common glucose-reducing drugs as well as prevention of metabolic impairment and special behavioral training,including the control over the level of glycemia, are used in treatment of diabetes mellitus induced by neuroleptics.
本文以下各部分将描述抗精神病药物（典型和非典型抗精神病药）的作用：抗精神病药物与碳水化合物代谢、预防及危险因素、药物流行病学、治疗。得出的结论是，抗精神病药物治疗会增加代谢损害的风险。目前这种作用的机制尚不清楚。种族、性别、年龄和治疗特点可能起一定作用。氯氮平、奥氮平、齐拉西酮、舍吲哚以及一些典型抗精神病药也是危险因素。常用的降糖药物以及代谢损害的预防和特殊行为训练，包括血糖水平控制，都用于治疗抗精神病药所致糖尿病。
