利用色氨酸2,3-双加氧酶基因敲除小鼠分析色氨酸2,3-双加氧酶和吲哚胺2,3-双加氧酶对D-色氨酸转化为烟酰胺的贡献。
Contributions of tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase to the conversion of D-tryptophan to nicotinamide analyzed by using tryptophan 2,3-dioxygenase-knockout mice.
作者信息
Maeta Akihiro, Sano Mitsue, Fukuwatari Tsutomu, Funakoshi Hiroshi, Nakamura Toshikazu, Shibata Katsumi
机构信息
a Department of Nutrition , School of Human Cultures, The University of Shiga Prefecture , Hikone , Japan.
出版信息
Biosci Biotechnol Biochem. 2014;78(5):878-81. doi: 10.1080/09168451.2014.905185. Epub 2014 May 15.
We investigated the contribution percentage of tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) to the conversion of D-tryptophan to nicotinamide in TDO-knockout mice. The calculated percentage conversions indicated that TDO and IDO oxidized 70 and 30%, respectively, of the dietary L-tryptophan. These results indicate that both TDO and IDO biosynthesize nicotinamide from D-tryptophan and L-tryptophan in mice.
我们研究了色氨酸2,3-双加氧酶（TDO）和吲哚胺2,3-双加氧酶（IDO）对TDO基因敲除小鼠中D-色氨酸向烟酰胺转化的贡献百分比。计算得出的转化率表明，TDO和IDO分别氧化了饮食中70%和30%的L-色氨酸。这些结果表明，在小鼠中，TDO和IDO均可从D-色氨酸和L-色氨酸生物合成烟酰胺。
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