Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cell. 2014 Jul 17;158(2):247-249. doi: 10.1016/j.cell.2014.06.043.
The intramembrane protease γ-secretase is a key player in signaling and Alzheimer's disease, but its structural features have remained obscure. A structure reported recently reveals a horseshoe-shaped arrangement of 19 transmembrane helices and an extracellular domain positioned for substrate recognition. This advance bodes well for a finer resolution before long.
跨膜蛋白酶 γ-分泌酶是信号转导和阿尔茨海默病中的关键分子，但它的结构特征一直不为人知。最近报道的一个结构揭示了 19 个跨膜螺旋的马蹄形排列和位于细胞外域以进行底物识别的位置。这一进展预示着不久的将来将会有更高分辨率的结构出现。
