6-O-酰基-D-阿洛糖对人白血病MOLT-4F细胞系的抗增殖活性。
Anti-proliferative activity of 6-O-acyl-D-allose against the human leukemia MOLT-4F cell line.
作者信息
Yanagita Ryo C, Kobashi Katsuya, Ogawa Chisa, Ashida Yoshiki, Yamaashi Haruka, Kawanami Yasuhiro
机构信息
a Faculty of Agriculture, Department of Applied Biological Science , Kagawa University , Miki-cho , Kagawa , 761-0795 , Japan.
出版信息
Biosci Biotechnol Biochem. 2014;78(2):190-4. doi: 10.1080/09168451.2014.882747. Epub 2014 Apr 14.
The anti-proliferative activities of the 6-O-acyl derivatives of D-allose against the human leukemia MOLT-4F cell line were examined. The activity of the 6-O-dodecanoyl derivative (3) was approximately 30 times stronger than that of D-allose. An evaluation of the derivatives of 3 that occurred in a furanose form revealed the pyranose forms of 3 to be important for the anti-proliferative activity.
研究了D-阿洛糖的6-O-酰基衍生物对人白血病MOLT-4F细胞系的抗增殖活性。6-O-十二烷酰基衍生物（3）的活性比D-阿洛糖强约30倍。对以呋喃糖形式存在的3的衍生物进行评估发现，3的吡喃糖形式对抗增殖活性很重要。
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