1991年至2011年日本札幌疫苗接种前时代流行的A组人轮状病毒G2P[4]株VP7基因的纵向分析。

Longitudinal analysis of VP7 gene of group A human rotavirus G2P[4] strains circulating in the pre-vaccine era in Sapporo, Japan from 1991 to 2011.

作者信息

Tatsumi Masatoshi, Nagaoka Yoshinobu, Tsugawa Takeshi, Yoto Yuko, Hori Tsukasa, Tsutsumi Hiroyuki

机构信息

Department of Pediatrics, Sapporo Medical University School of Medicine, South-1, West-16, Sapporo, 060-8543, Japan; Otaru Kyokai Hospital, Otaru City, Japan.

出版信息

Microbiol Immunol. 2014 Sep;58(9):540-4. doi: 10.1111/1348-0421.12182.

DOI:10.1111/1348-0421.12182

PMID:25040726

Abstract

Sequence analysis of the VP7 gene in 23 group A human rotavirus G2P[4] strains obtained during 1991-2011, that is, the pre-vaccine era, in Sapporo, Japan showed considerable genetic diversity, mainly in variable regions. Recent G2P[4] epidemic strains were located in sublineage IVa with a distinctive substitution of D96N. This study provides background data on the genetic variability of G2P[4] rotavirus-VP7 gene prior to the widespread use of rotavirus vaccines in Japan.

摘要

对1991年至2011年（即疫苗接种前时代）在日本札幌获得的23株A组人轮状病毒G2P[4]毒株的VP7基因进行序列分析，结果显示存在相当大的遗传多样性，主要集中在可变区。近期的G2P[4]流行毒株位于亚谱系IVa，具有D96N的独特替换。本研究提供了在日本广泛使用轮状病毒疫苗之前G2P[4]轮状病毒VP7基因遗传变异性的背景数据。