Majone F, Busulini L, Capozzi A, Bianco N, Saggioro D, Levis A G, Bordin F
Department of Biology, University of Padua, Italy.
Mutat Res. 1989 Sep;227(1):17-20. doi: 10.1016/0165-7992(89)90062-6.
We studied the DNA replicon size in BALB/c and BALB/Mo mouse lymphocytes by the method of bromodeoxyuridine photolysis. After treatment of the BALB/Mo lymphocytes in vitro with mitomycin C, the average DNA replicon size appeared to be significantly smaller than that observed in BALB/c lymphocytes treated similarly. In these conditions an increased susceptibility to SCE induction in BALB/Mo lymphocytes had been observed. In the presence of both mitomycin C and cordycepin (an antiviral drug), both the DNA replicon size and the SCE frequency returned to normal values.
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