[慢性淋巴细胞白血病合并中枢神经系统浸润：1例报告及文献复习]
[Chronic lymphocytic leukemia with central nervous system invasion: one case report and literature review].
作者信息
Zhu Jianfeng, Wu Zhengdong, Fan Lei, Xu Wei, Li Jianyong
机构信息
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2014 Jul;35(7):592-5. doi: 10.3760/cma.j.issn.0253-2727.2014.07.004.
OBJECTIVE
To investigate clinical features, diagnosis, therapy, and prognosis in a case of chronic lymphocytic leukemia (CLL) with central nervous system (CNS) invasion.
METHODS
The cellular morphology of bone marrow, cytology and flow cytometry of cells in CSF, and radiographic manifestations were detected in a patient diagnosed as CLL with CNS invasion. The clinical features, pathogenesis, diagnosis,therapy, and prognosis of CLL with CNS invasion were reviewed by literatures.
RESULTS
A clonal population of B lymphocytes with typical characteristics of immunophenotype was identified in the patient. After treated with intrathecal chemotherapy, the patient returned to normal cells count of cerebrospinal fluid and normal neurologic status. Previous studies also have demonstrated the efficacy of intrathecal chemotherapy.
CONCLUSION
CNS invasion is a rare complication of CLL. Early detection and treatment may result in better outcomes.
目的
探讨1例慢性淋巴细胞白血病（CLL）合并中枢神经系统（CNS）浸润患者的临床特征、诊断、治疗及预后。
方法
对1例诊断为CLL合并CNS浸润的患者进行骨髓细胞形态学、脑脊液细胞细胞学及流式细胞术检测，以及影像学表现检查。通过文献复习CLL合并CNS浸润的临床特征、发病机制、诊断、治疗及预后。
结果
该患者中鉴定出具有典型免疫表型特征的B淋巴细胞克隆群体。经鞘内化疗治疗后，患者脑脊液细胞计数恢复正常，神经状态恢复正常。既往研究也证实了鞘内化疗的疗效。
结论
CNS浸润是CLL的一种罕见并发症。早期发现和治疗可能会带来更好的结果。
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