Department of Neurosciences, Moores UCSD Cancer Center, University of California at San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA.
J Neurooncol. 2012 Jan;106(1):185-200. doi: 10.1007/s11060-011-0636-z. Epub 2011 Jul 17.
Central nervous system (CNS) involvement is a rare complication of chronic lymphocytic leukemia (CLL) with varied outcomes. We contribute two additional cases of CLL with CNS involvement. The clinical course and response to treatment are described. All 78 previously reported cases of CLL with CNS involvement are presented in this comprehensive review of the literature. CNS involvement of CLL is a rare complication that does not seem to correlate with any evident risk factors. Resolution of CNS symptoms can often be accomplished with intrathecal chemotherapy or irradiation. Early detection and treatment may result in better outcomes in this rare complication.
中枢神经系统（CNS）受累是慢性淋巴细胞白血病（CLL）的罕见并发症，其结局各异。我们提供了另外 2 例 CLL 合并 CNS 受累的病例。描述了其临床经过和治疗反应。通过对文献的全面回顾，共纳入了此前报道的 78 例 CLL 合并 CNS 受累的病例。CLL 合并 CNS 受累是一种罕见的并发症，似乎与任何明显的危险因素无关。CNS 症状的缓解通常可以通过鞘内化疗或放疗来实现。早期发现和治疗可能会改善这种罕见并发症的结局。
