挪威青少年人群中的维生素D缺乏与生活方式风险因素

Vitamin D deficiency and lifestyle risk factors in a Norwegian adolescent population.

作者信息

Oberg Johanna, Jorde Rolf, Almås Bjørg, Emaus Nina, Grimnes Guri

机构信息

Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway

Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway University Hospital of North Norway, Division of Internal Medicine, Tromsø, Norway.

出版信息

Scand J Public Health. 2014 Nov;42(7):593-602. doi: 10.1177/1403494814541593. Epub 2014 Jul 22.

DOI:10.1177/1403494814541593

PMID:25053469

Abstract

AIM

The aim was to study vitamin D status in a healthy adolescent Norwegian population at 69°N.

METHODS

The data presented come from The Tromsø Study: Fit Futures, during the school year 2010/2011 (not including the summer months), where 1,038 (92% of those invited) participated. Physical examinations, questionnaires and blood samples were collected, and serum 25-hydroxyvitamin D (25(OH)D) were analyzed using LC-MS/MS.

RESULTS

RESULTS are presented from 475 boys and 415 girls (15-18 years old) with available blood samples. A total of 60.2% had vitamin D deficiency or insufficiency (serum 25(OH)D <50 nmol/l), 16.5% were deficient (<25 nmol/l) and 1.6% had severe vitamin D deficiency (<12.5 nmol/l). Only 12.4% had levels >75 nmol/l. A significant gender difference with a mean (SD) serum 25(OH)D level of 40.5 (20.5) nmol/l in boys and 54.2 (23.2) nmol/l in girls (p <0.01) was present. Furthermore, 51.3% of girls had levels >50 nmol/l in comparison to 29.7% of boys (p <0.01). There was an inverse correlation between parathyroid hormone levels and 25(OH)D, rs= -0.30 (p<0.01). Explanatory factors that were significantly associated with serum 25(OH)D levels in multivariate models were use of snuff, consumption of vitamin D fortified milk, cod liver oil and vitamin/mineral supplements, physical activity, sunbathing holiday and use of solarium in boys, and vitamin/mineral supplements, physical activity, sunbathing holiday and use of solarium in girls .

CONCLUSIONS

Vitamin D deficiency is prevalent during the school year among adolescents in northern Norway, particularly among boys.

摘要

目的

本研究旨在调查北纬69°的挪威健康青少年群体的维生素D状况。

方法

本研究数据来自特罗姆瑟研究：健康未来项目，研究时间为2010/2011学年（不包括夏季月份），共有1038人（占受邀人数的92%）参与。研究收集了参与者的体格检查、问卷调查及血样，并采用液相色谱 - 串联质谱法（LC-MS/MS）分析血清25-羟基维生素D（25(OH)D）水平。

结果

本研究结果来自475名男孩和415名女孩（年龄在15 - 18岁），他们均有可用血样。共有60.2%的人存在维生素D缺乏或不足（血清25(OH)D<50 nmol/l），16.5%的人维生素D缺乏（<25 nmol/l），1.6%的人存在严重维生素D缺乏（<12.5 nmol/l）。只有12.4%的人血清25(OH)D水平>75 nmol/l。男孩血清25(OH)D平均（标准差）水平为40.5（20.5）nmol/l，女孩为54.2（23.2）nmol/l，存在显著性别差异（p<0.01）。此外，51.3%的女孩血清25(OH)D水平>50 nmol/l，而男孩这一比例为29.7%（p<0.01）。甲状旁腺激素水平与25(OH)D呈负相关，rs = -0.30（p<0.01）。在多变量模型中，与血清25(OH)D水平显著相关的解释因素包括：男孩使用鼻烟、饮用维生素D强化牛奶、食用鱼肝油及维生素/矿物质补充剂、身体活动、晒日光浴假期及使用日光浴室；女孩使用维生素/矿物质补充剂、身体活动、晒日光浴假期及使用日光浴室。