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腹腔镜电灼术与二氧化碳激光消融术治疗骨盆较小的子宫内膜异位症女性疼痛症状的疗效比较

Treatment efficacy for pain complaints in women with endometriosis of the lesser pelvis after laparoscopic electroablation vs. CO2 laser ablation.

作者信息

Posadzka Ewa, Jach Robert, Pityński Kazimierz, Jablonski Marcin Jacek

机构信息

Departament of Gynecology and Obstetrics, Jagiellonian University Medical College, 23 Kopernika str, 31-501, Krakow, Poland.

出版信息

Lasers Med Sci. 2015 Jan;30(1):147-52. doi: 10.1007/s10103-014-1630-4. Epub 2014 Jul 23.

Abstract

Endometriosis is a chronic disease affecting mainly women of the reproductive age. Its most common manifestations include impaired fecundity, pelvic pain, and dyschezia. Laparoscopic removal of endometriotic foci remains to be the gold standard for the treatment of endometriosis. More effective techniques of endoscopic approach-among others, laser application-are continually being developed. The aim of the study was to evaluate the efficacy of laparoscopic treatment with the use of CO2 laser ablation vs. electroablation with regard to pain complaints in the affected patients. The study included 48 women (aged 22-42) with varying degrees of endometriosis of the lesser pelvis. The Numeric Rating Scale (NRS) was used to evaluate pain intensity before the surgery in all patients, followed by either laser ablation or electroablation of the endometriotic foci. The results of the laparoscopic treatment were monitored after 3 and 6 months postoperatively. p value of 0.05 was considered to be statistically significant. Patients from both groups reported less intensive pain before/during menstruation (dysmenorrhea) 6 months postoperatively, with more distinct tendency in the electroablation group (p = 0.004) as compared to the laser ablation group (p = 0.025). Despite the initial improvement reported at the 3-month checkup (p = 0.008), 6 months postoperatively, a statistically significant increase in pain intensity was noted in both groups (p = 0.016 and p = 0.032 for CO2 laser ablation and electroablation, respectively). Both surgical methods seem to be effective only in the treatment of endometriosis-related dysmenorrhea, whereas the intensity of other pain complaints (dyspareunia, dysuria, dyschezia, pelvic pain syndrome (PPS)) has remained on the same level.

摘要

子宫内膜异位症是一种主要影响育龄女性的慢性疾病。其最常见的表现包括生育力受损、盆腔疼痛和排便困难。腹腔镜切除子宫内膜异位病灶仍然是治疗子宫内膜异位症的金标准。内镜治疗的更有效技术——其中包括激光应用——正在不断发展。本研究的目的是评估使用二氧化碳激光消融与电消融的腹腔镜治疗对受影响患者疼痛主诉的疗效。该研究纳入了48名年龄在22至42岁之间、患有不同程度盆腔子宫内膜异位症的女性。使用数字评定量表(NRS)评估所有患者手术前的疼痛强度,随后对子宫内膜异位病灶进行激光消融或电消融。术后3个月和6个月监测腹腔镜治疗的结果。p值为0.05被认为具有统计学意义。两组患者术后6个月均报告经前/经期疼痛(痛经)减轻,与激光消融组(p = 0.025)相比,电消融组的趋势更明显(p = 0.004)。尽管在3个月检查时报告有初步改善(p = 0.008),但术后6个月,两组患者的疼痛强度均有统计学意义的增加(二氧化碳激光消融组和电消融组分别为p = 0.016和p = 0.032)。两种手术方法似乎仅对与子宫内膜异位症相关的痛经有效,而其他疼痛主诉(性交困难、排尿困难、排便困难、盆腔疼痛综合征(PPS))的强度保持在同一水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e62/4289154/a51e48d26fb5/10103_2014_1630_Fig1_HTML.jpg

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