产青霉素的产黄青霉工业祖代菌株P2niaD18的全基因组测序及染色体水平基因组组装
Complete Sequencing and Chromosome-Scale Genome Assembly of the Industrial Progenitor Strain P2niaD18 from the Penicillin Producer Penicillium chrysogenum.
作者信息
Specht Thomas, Dahlmann Tim A, Zadra Ivo, Kürnsteiner Hubert, Kück Ulrich
机构信息
Sandoz GmbH, Kundl, Austria.
Christian Doppler Laboratory for Fungal Biotechnology, Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, Bochum, Germany.
出版信息
Genome Announc. 2014 Jul 24;2(4):e00577-14. doi: 10.1128/genomeA.00577-14.
Abstract
Penicillium chrysogenum is the major industrial producer of the β-lactam antibiotic penicillin. Here, we report the complete genome sequence of the industrial progenitor strain P. chrysogenum P2niaD18 in a chromosome-scale genome assembly. P2niaD18 is distinguished from the recently sequenced P. chrysogenum Wisconsin 54-1255 strain by major chromosomal rearrangements leading to a modified chromosomal architecture.
摘要
产黄青霉是β-内酰胺抗生素青霉素的主要工业生产菌株。在此，我们报告了工业祖代菌株产黄青霉P2niaD18在染色体水平基因组组装下的完整基因组序列。P2niaD18与最近测序的产黄青霉Wisconsin 54-1255菌株的区别在于主要的染色体重排，导致染色体结构发生改变。
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