Johnston C, Webb L, Daley J, Spathis G S
Department of Medicine, St Helier Hospital, Carshalton, Surrey.
J R Soc Med. 1989 Aug;82(8):479-83. doi: 10.1177/014107688908200811.
Three cases are presented which emphasize the importance of hyponatraemia as a cause of grand mal seizures. The combination of hydrochlorothiazide and amiloride appears to increase the risk of hyponatraemia. We discuss the aetiology and treatment of hyponatraemia and review the necessity for such combination therapy. We recommend caution in prescribing diuretics and preparations such as Moduretic should be used only in those few patients shown to need potassium supplementation.
本文介绍了三例病例,强调了低钠血症作为癫痫大发作病因的重要性。氢氯噻嗪和阿米洛利联合使用似乎会增加低钠血症的风险。我们讨论了低钠血症的病因和治疗方法,并回顾了这种联合治疗的必要性。我们建议在开具利尿剂时要谨慎,像Moduretic这类制剂仅应用于少数显示需要补充钾的患者。