Fava Luca L, Villunger Andreas
Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
EMBO J. 2014 Sep 1;33(17):1849-51. doi: 10.15252/embj.201489466. Epub 2014 Jul 25.
According to current belief, the molecular networks orchestrating cell death or exit from mitosis upon extended mitotic arrest do not interact, stubbornly executing two parallel biological programs and competing to define a stochastic decision between death and a chance for survival with uncertain destiny. However, recent findings by Diaz-Martinez (2014) in this issue of now call for a reassessment of the “competing network” hypothesis.
根据目前的观点,在有丝分裂长期停滞时协调细胞死亡或退出有丝分裂的分子网络并不相互作用,而是固执地执行两个平行的生物学程序,并竞争来确定一个介于死亡和命运不确定的生存机会之间的随机决定。然而,迪亚兹 - 马丁内斯(2014年)在本期杂志上的最新发现,现在需要对“竞争网络”假说进行重新评估。