Duray A, Demoulin S, Petermans J, Moutschen M, Saussez S, Jerusalem G, Delvenne P
Rev Med Liege. 2014 May-Jun;69(5-6):276-81.
In Belgium and in other countries, the Cancer Registry data show an increased incidence of cancers related to age, the majority of tumors being diagnosed beyond 60 years. However, the mechanisms responsible for this increase are not clear. Cancer could be chronologically associated with aging because of the long latency period between the exposition to carcinogenic agents and the appearance of clinical signs. Aging could also predispose directly to cancer by different mechanisms (impaired immune response, increased oxidative stress, shortening of telomeres, accumulation of senescent cells). In this review, we propose to describe different hypotheses which could explain the increased incidence of cancers in the elderly.
在比利时和其他国家，癌症登记数据显示与年龄相关的癌症发病率有所上升，大多数肿瘤在60岁以后被诊断出来。然而，导致这种上升的机制尚不清楚。由于接触致癌物质与临床症状出现之间存在较长的潜伏期，癌症可能在时间上与衰老相关。衰老也可能通过不同机制（免疫反应受损、氧化应激增加、端粒缩短、衰老细胞积累）直接诱发癌症。在这篇综述中，我们建议描述不同的假说，这些假说可以解释老年人癌症发病率的上升。
