Okuyama K, Onoda S, Tohnosu N, Koide Y, Awano T, Ozaki M, Ochiai T, Gunji Y, Matsubara H, Kinoshita H
Second Dept. of Surgery, Chiba University.
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2932-5.
Between 1977 and April in 1989, long-term survivors (over two years) by intra-arterial infusion chemotherapy in gastric cancer patients with liver metastases were examined. The materials were 5 patients (4 synchronous, 1 metachronous metastases) among 21 P0H (+) gastric cancers. The extent of liver metastases shows 1 H1 and 4 H2. Reduction surgery was performed in 4 H2 patients (2 S2 + 3, 1 S4, 1 S6) and postoperative intra-arterial infusion chemotherapy via the catheter in the common hepatic artery was done to control the residual liver metastases. Continuous intra-arterial infusion chemotherapy with the regimen of FML (5-FU, MMC, Lentinan) revealed 100% response rate (3 CR, 1 PR). In a patient with metachronous metastases, PR was obtained with MA (MMC, ADM) + one-shot intra-arterial infusion of LAK cells. Among 5 patients, one with synchronous metastases has survived 35 months, followed by a patient who died after 32 months and two patients who died after 27 months. A patient with metachronous metastases has survived for 24 months.
1977年至1989年4月期间，对胃癌肝转移患者采用动脉内灌注化疗的长期存活者（超过两年）进行了检查。材料为21例P0H(+)胃癌中的5例患者（4例同时性转移，1例异时性转移）。肝转移范围显示为1例H1和4例H2。对4例H2患者（2例S2 + 3，1例S4，1例S6）进行了缩小手术，并通过肝总动脉内的导管进行术后动脉内灌注化疗以控制残留的肝转移。采用FML（5-氟尿嘧啶、丝裂霉素、香菇多糖）方案进行持续动脉内灌注化疗，有效率达100%（3例完全缓解，1例部分缓解）。在1例异时性转移患者中，采用MA（丝裂霉素、阿霉素）+一次性动脉内输注LAK细胞获得了部分缓解。5例患者中，1例同时性转移患者存活了35个月，其次是1例32个月后死亡的患者和2例27个月后死亡的患者。1例异时性转移患者存活了24个月。
