J Clin Oncol. 2014 Aug 20;32(24):2553-61. doi: 10.1200/JCO.2014.55.3073.
Nearly half of all women diagnosed with breast or ovarian cancer are age 65 years or older with the number of women diagnosed expected to increase as the population ages and life expectancy improves. Older women are less likely to be offered standard cancer treatments, are more likely to develop higher toxicity, and have higher mortality. Chronologic age should not be the only factor used for making treatment decisions. Functional dependence, organ function, comorbidity, polypharmacy, social support, cognitive and/or psychosocial factors, overall life expectancy, and patient's goals of care are equally vital and should be assessed before and during treatment. In this review, current evidence and treatment guidelines for older women with breast or ovarian cancer are outlined.
近一半被诊断患有乳腺癌或卵巢癌的女性年龄在 65 岁或以上,随着人口老龄化和预期寿命的提高,被诊断患有此类疾病的女性人数预计将会增加。与年轻女性相比,老年女性接受标准癌症治疗的可能性较低,更容易出现更高的毒性,死亡率也更高。因此,不能仅仅依据年龄来做出治疗决策。在制定治疗决策时,还应考虑功能依赖性、器官功能、合并症、多种药物治疗、社会支持、认知和/或社会心理因素、总预期寿命以及患者的治疗目标等因素。在本综述中,概述了针对患有乳腺癌或卵巢癌的老年女性的现有证据和治疗指南。