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有机肝细胞中痕量有毒铀离子的诊断

Diagnosis of trace toxic uranium ions in organic liver cell.

作者信息

Ly Suw Young, Pack Eun Chul, Choi Dal Woong

机构信息

Biosensor Biosensor Research Institute, Seoul National University of Technology, Seoul, Korea.

Department of Public Health Science, Graduate School, Korea University, Seoul, Korea.

出版信息

Toxicol Res. 2014 Jun;30(2):117-20. doi: 10.5487/TR.2014.30.2.117.

Abstract

Uranium is toxic and radioactive traces of it can be found in natural water and soils. High concentrations of it in biological systems cause genetic disorders and diseases. For the in vivo diagnosis, micro and nano range detection limits are required. Here, an electrochemical assay for trace toxic uranium was searched using stripping voltammetry. Renewable and simplified graphite pencils electrode (PE) was used in a three-electrode cell system. Seawater was used instead of an electrolyte solution. This setup can yield good results and the detection limit was attained to be at 10 μgL(-1). The developed skill can be applied to organic liver cell.

摘要

铀具有毒性,在天然水和土壤中可发现其放射性痕迹。生物系统中高浓度的铀会导致遗传紊乱和疾病。对于体内诊断,需要达到微纳范围的检测限。在此,利用溶出伏安法探寻了一种用于痕量有毒铀的电化学检测方法。在三电极电池系统中使用了可再生且简化的石墨铅笔电极(PE)。使用海水替代电解质溶液。该装置能产生良好结果,检测限达到10 μg/L。所开发的技术可应用于有机肝细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c050/4112062/1be3f3f9b197/toxicr-30-117-g0001.jpg

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