Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden
Anticancer Res. 2014 Aug;34(8):3867-73.
The RECK (reversion-inducing cysteine-rich protein with Kazal motifs) gene is a relatively newly discovered gene with important implications in cancer biology. RECK is normally expressed in all cells of the body and has an important role in the balance between destructive and constructive features of the extracellular matrix (ECM). The RECK protein is a membrane-bound glycoprotein that inhibits matrix metalloproteinases with the function of breaking-down the ECM. There is a significant correlation between RECK gene expression and the formation of new vessels, presumably via the mediation of vascular endothelial growth factor (VEGF), which is an important and powerful inducer of angiogenesis. Research has shown that down-regulation of RECK is caused by the rat sarcoma oncogene (RAS), which is also a common cause of tumor development in the early stages. For a tumor to progress and gain characteristics that classifies it as malignant, the degradation of the ECM and mobilization of new blood vessels are essential functions. If the tumor is inhibited with respect to these functions, it will cease to grow. RECK is, therefore, a potential tumor inhibitor but also a prognostic marker available at early clinical stages.
RECK（富含 Kazal 基序的反转诱导胱氨酸丰富蛋白）基因是一个相对较新发现的基因，在癌症生物学中有重要意义。RECK 通常在体内所有细胞中表达，在细胞外基质（ECM）的破坏性和建设性特征之间的平衡中具有重要作用。RECK 蛋白是一种膜结合糖蛋白，可抑制基质金属蛋白酶，具有破坏 ECM 的功能。RECK 基因表达与新血管的形成之间存在显著相关性，推测可能通过血管内皮生长因子（VEGF）的介导，VEGF 是血管生成的重要和强大诱导剂。研究表明，RECK 的下调是由大鼠肉瘤致癌基因（RAS）引起的，RAS 也是肿瘤早期发展的常见原因。为了使肿瘤进展并获得将其归类为恶性的特征，ECM 的降解和新血管的动员是必不可少的功能。如果肿瘤在这些功能上受到抑制，它将停止生长。因此，RECK 是一种潜在的肿瘤抑制剂，也是早期临床阶段可用的预后标志物。
