Donnelly Deirdre E, Morrison Patrick J
Regional Medical Genetics Centre, Queens University Belfast, Belfast City Hospital, Belfast, BT9 7AB, UK.
Regional Medical Genetics Centre, Queens University Belfast, Belfast City Hospital, Belfast, BT9 7AB, UK ; Centre for Cancer Research and molecular biology, Queens University Belfast, Belfast City Hospital, Belfast, BT9 7AB, UK.
Ulster Med J. 2014 May;83(2):86-8.
The biblical giant Goliath has an identifiable family tree suggestive of autosomal dominant inheritance. We suggest that he had a hereditary pituitary disorder possibly due to the AIP gene, causing early onset and familial acromegaly or gigantism. We comment on the evidence within the scriptures for his other relatives including a relative with six digits and speculate on possible causes of the six digits. Recognition of a hereditary pituitary disorder in the biblical Goliath and his family sheds additional information on his and other family members' battles with David and his relatives.
圣经中的巨人歌利亚有一个可识别的家族谱系，提示常染色体显性遗传。我们认为他患有遗传性垂体疾病，可能是由于AIP基因导致的，引发了早发性和家族性肢端肥大症或巨人症。我们对经文中关于他其他亲属的证据进行了评论，包括一个有六指的亲属，并推测了六指的可能原因。认识到圣经中的歌利亚及其家族患有遗传性垂体疾病，为他和其他家庭成员与大卫及其亲属的争斗提供了更多信息。
