Goldstein R B, Filly R A, Hecht S, Davis S
Department of Radiology, University of California School of Medicine, San Francisco 94143.
J Clin Ultrasound. 1989 Oct;17(8):553-62. doi: 10.1002/jcu.1870170803.
The sonograms of 71 low birth weight infants were retrospectively reviewed and compared with results of neuromotor examinations at 24 months of age to determine whether mild abnormalities commonly detected on cranial sonograms (including milder grades of hemorrhage, ventricular dilation, and noncystic increases in periventricular echogenicity) were correlated with future neurologic handicaps. Of the 71 infants studied, increased periventricular echoes were noted in 20 (28%), Grade 1 or 2 intracranial hemorrhage in 31 (43%), and mild-moderate ventriculomegaly in 28 (39%). Neuromotor handicaps were detected in 15 (21%). No significant correlation was found between the above sonographic abnormalities and the incidence of future neuromotor handicaps. When those neonates with asymmetric mild-moderate ventriculomegaly were separately analyzed, this group was found to have more neuromotor handicaps (p less than 0.05) than those with normal ventricular size, and this finding warrants future study. Importantly, early cranial sonograms were completely normal in 12% of those infants with neuromotor handicaps. We conclude that the presence of mild cranial sonographic abnormalities (including mildly increased periventricular echogenicity) in these infants is not well correlated with neuromotor handicaps detected at 24 months of age.
回顾性分析了71例低体重儿的超声图像，并与他们24个月大时的神经运动检查结果进行比较，以确定头颅超声检查中常见的轻度异常（包括较轻程度的出血、脑室扩张和脑室周围回声增强但无囊肿形成）是否与未来的神经功能障碍相关。在研究的71例婴儿中，20例（28%）出现脑室周围回声增强，31例（43%）出现1级或2级颅内出血，28例（39%）出现轻至中度脑室扩大。15例（21%）存在神经运动功能障碍。上述超声异常与未来神经运动功能障碍的发生率之间未发现显著相关性。对那些轻度至中度脑室扩大不对称的新生儿进行单独分析时，发现该组的神经运动功能障碍比脑室大小正常的新生儿更多（p<0.05），这一发现值得进一步研究。重要的是，在有神经运动功能障碍的婴儿中，12%的早期头颅超声检查完全正常。我们得出结论，这些婴儿中存在轻度头颅超声异常（包括脑室周围回声轻度增强）与24个月时检测到的神经运动功能障碍并无很好的相关性。
