Barzilai B, Eisen H E
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
J Clin Ultrasound. 1989 Oct;17(8):579-84. doi: 10.1002/jcu.1870170807.
To improve the sensitivity and reliability of the ultrasonic detection of intravascular thrombosis, we employed quantitative ultrasonic techniques for the analysis of thrombi induced in vitro. Citrated human blood or platelet-rich plasma was added to sections of canine thoracic aorta mounted vertically in a saline bath. CaCl2 and thrombin were then added to induce thrombosis. Ultrasonic integrated backscatter measured sequentially with a 10-MHz focused transducer exhibited more than a 10 dB increase in integrated backscatter when either whole blood or platelet-rich plasma was clotted (-61.7 dB to -47.4 dB whole blood; less than -70 dB to -52.8 dB platelet-rich plasma). Thus, large significant changes in integrated backscatter measured from structures within the arterial lumen were readily detectable and indicative of thrombosis in situ.
为提高血管内血栓超声检测的灵敏度和可靠性，我们采用定量超声技术分析体外诱导形成的血栓。将枸橼酸盐抗凝的人血或富含血小板的血浆加入垂直置于盐浴中的犬胸主动脉切片中。然后加入氯化钙和凝血酶以诱导血栓形成。当全血或富含血小板的血浆凝固时，用10MHz聚焦换能器顺序测量的超声背向散射积分显示背向散射积分增加超过10dB（全血从-61.7dB至-47.4dB；富含血小板的血浆从小于-70dB至-52.8dB）。因此，从动脉管腔内结构测量的背向散射积分的显著大变化很容易检测到，并表明原位血栓形成。
