Kashani Amir H, Cheung Albert Y, Robinson Joshua, Williams George A
*Department of Ophthalmology, University of Southern California, Los Angeles, California; †Department of Ophthalmology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan; and ‡Department of Vitreoretinal Surgery, Oakland University William Beaumont School of Medicine, Associated Retinal Consultants PC, Royal Oak, Michigan.
Retina. 2015 Jan;35(1):149-56. doi: 10.1097/IAE.0000000000000267.
To investigate optical coherence tomography-derived reflectivity and optical density (OD) characteristics of persistent subretinal fluid (SRF) in eyes after surgical repair of macula-off rhegmatogenous retinal detachment.
Retrospective case series of nine eyes with macula-off rhegmatogenous retinal detachment that underwent surgical repair with either scleral buckling or vitrectomy with or without scleral buckling. Major inclusion criteria included 1) availability of high-quality optical coherence tomography scans at 2 or more time points, and 2) sufficient SRF for optical coherence tomography sampling without including tissue edges. Demographic, clinical, and optical coherence tomography imaging data were collected on all eyes. Optical density and SRF height measurements were obtained using a manual image segmentation method with ImageJ. Optical density measurements were standardized by conversion to optical density ratios to facilitate comparison between different visits and eyes. Correlations were assessed for significance through both univariate and multivariate regression analyses.
Optical density ratio measurements increased with time after surgery, and this was statistically significant (P = 0.001, R = 0.331). Subretinal fluid height measurements decreased in all eyes. There was a significant correlation between optical density ratios and log of SRF height (P ≤ 0.001, R = 0.485). In multivariate analysis, neither optical density ratios nor SRF height was a statistically significant predictor of visual acuity.
Changes in optical density ratios of the residual SRF after retinal detachment repair may be representative of changes in the SRF composition over time. This is in agreement with previous biochemical studies and may serve as a noninvasive method of assessing SRF content in vivo.
研究黄斑脱离性孔源性视网膜脱离手术修复后眼中持续性视网膜下液（SRF）的光学相干断层扫描衍生反射率和光密度（OD）特征。
对9例黄斑脱离性孔源性视网膜脱离患者的病例系列进行回顾性研究，这些患者接受了巩膜扣带术或玻璃体切除术（伴或不伴巩膜扣带术）进行手术修复。主要纳入标准包括：1）在2个或更多时间点可获得高质量的光学相干断层扫描图像；2）有足够的视网膜下液用于光学相干断层扫描采样且不包括组织边缘。收集所有患者的人口统计学、临床和光学相干断层扫描成像数据。使用ImageJ通过手动图像分割方法获得光密度和视网膜下液高度测量值。通过转换为光密度比来标准化光密度测量值，以方便不同就诊时间和不同眼睛之间的比较。通过单变量和多变量回归分析评估相关性的显著性。
光密度比测量值在术后随时间增加，且具有统计学显著性（P = 0.001，R = 0.331）。所有患者的视网膜下液高度测量值均下降。光密度比与视网膜下液高度的对数之间存在显著相关性（P≤0.001，R = 0.485）。在多变量分析中，光密度比和视网膜下液高度均不是视力的统计学显著预测指标。
视网膜脱离修复后残余视网膜下液的光密度比变化可能代表视网膜下液成分随时间的变化。这与先前的生化研究一致，并且可作为一种体内评估视网膜下液含量的非侵入性方法。
