人疱疹病毒8通过gp130的病毒白细胞介素-6信号传导促进原发性渗出性淋巴瘤和内皮细胞中的病毒复制。
Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells.
作者信息
Cousins Emily, Gao Yang, Sandford Gordon, Nicholas John
机构信息
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
出版信息
J Virol. 2014 Oct;88(20):12167-72. doi: 10.1128/JVI.01751-14. Epub 2014 Jul 30.
Abstract
The contributions of human herpesvirus 8 (HHV-8) viral interleukin-6 (vIL-6) to virus biology remain unclear. Here we examined the role of vIL-6/gp130 signaling in HHV-8 productive replication in primary effusion lymphoma and endothelial cells. Depletion and depletion-complementation experiments revealed that endoplasmic reticulum-localized vIL-6 activity via gp130 and gp130-activated signal transducer and activator of transcription (STAT) signaling, but not extracellular signal-regulated kinase (ERK) activation, was critical for vIL-6 proreplication activity. Our data significantly extend current understanding of vIL-6 function and associated mechanisms in HHV-8 biology.
摘要
人类疱疹病毒8型（HHV - 8）的病毒白细胞介素6（vIL - 6）对病毒生物学的贡献仍不清楚。在此，我们研究了vIL - 6/gp130信号传导在原发性渗出性淋巴瘤和内皮细胞中HHV - 8生产性复制中的作用。缺失和缺失互补实验表明，通过gp130和gp130激活的信号转导和转录激活因子（STAT）信号传导的内质网定位的vIL - 6活性，而非细胞外信号调节激酶（ERK）激活，对vIL - 6的促复制活性至关重要。我们的数据显著扩展了目前对HHV - 8生物学中vIL - 6功能及相关机制的理解。
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