如今的卡波西肉瘤与 40 年前已大不相同，不是吗？
Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it?
机构信息
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
出版信息
J Med Virol. 2023 May;95(5):e28773. doi: 10.1002/jmv.28773.
Abstract
This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that manifests under diverse and divergent circumstances. We begin with a historical introduction of KS and KS-associated herpesvirus (KSHV), highlight the diversity of clinical presentations of KS, summarize what we know about the cell of origin for this tumor, explore KSHV viral load as a potential biomarker for acute KSHV infections and KS-associated complications, and discuss immune modulators that impact KSHV infection, KSHV persistence, and KS disease.
摘要
这篇综述将概述卡波西肉瘤（KS）是一种在不同和不同情况下表现出来的疾病的概念。我们首先对 KS 和 KS 相关疱疹病毒（KSHV）进行历史介绍，强调 KS 的临床表现多样性，总结我们对这种肿瘤起源细胞的了解，探讨 KSHV 病毒载量作为急性 KSHV 感染和 KS 相关并发症的潜在生物标志物，并讨论影响 KSHV 感染、KSHV 持续存在和 KS 疾病的免疫调节剂。
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