Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Med Virol. 2023 May;95(5):e28773. doi: 10.1002/jmv.28773.
This review will provide an overview of the notion that Kaposi sarcoma (KS) is a disease that manifests under diverse and divergent circumstances. We begin with a historical introduction of KS and KS-associated herpesvirus (KSHV), highlight the diversity of clinical presentations of KS, summarize what we know about the cell of origin for this tumor, explore KSHV viral load as a potential biomarker for acute KSHV infections and KS-associated complications, and discuss immune modulators that impact KSHV infection, KSHV persistence, and KS disease.
这篇综述将概述卡波西肉瘤（KS）是一种在不同和不同情况下表现出来的疾病的概念。我们首先对 KS 和 KS 相关疱疹病毒（KSHV）进行历史介绍，强调 KS 的临床表现多样性，总结我们对这种肿瘤起源细胞的了解，探讨 KSHV 病毒载量作为急性 KSHV 感染和 KS 相关并发症的潜在生物标志物，并讨论影响 KSHV 感染、KSHV 持续存在和 KS 疾病的免疫调节剂。
