韩国血友病患者免疫异常的综合研究。

A comprehensive study of immunological abnormalities in Korean hemophiliacs.

作者信息

Kim K Y, Yang C H, Kang S H, Kim D S

出版信息

Yonsei Med J. 1989;30(2):180-5. doi: 10.3349/ymj.1989.30.2.180.

DOI:10.3349/ymj.1989.30.2.180

Abstract

To determine laboratory evidence suggesting immunological abnormalities in persons with hemophilia, we evaluated the immunological status of 75 Korean hemophiliacs, seronegative for human immunodeficiency virus (HIV) antibodies, who have been treated only with Korean factor VIII concentrates. From this study, it was shown that Korean hemophiliacs had decreased CD4 levels, increased CD8 levels, and decreased CD4:CD8 ratios. Diminished lymphocyte response to the mitogens, phytohemagglutinin and concanavalin A, and decreased natural killer cell activity were observed in the hemophiliacs. In addition, production of interleukin-II in the hemophiliacs was lower than in the healthy controls. The percentage of B lymphocytes was significantly reduced but the serum levels of immunoglobulin (Ig) G were elevated. However, the serum Ig A and Ig M levels were normal. This study demonstrated a high frequency of immunological abnormalities in HIV antibody negative Korean hemophiliacs treated only with domestic factor VIII concentrates.

摘要

为了确定提示血友病患者存在免疫异常的实验室证据，我们评估了75名韩国血友病患者的免疫状态，这些患者人类免疫缺陷病毒（HIV）抗体血清学阴性，仅接受韩国产的凝血因子VIII浓缩剂治疗。从这项研究中可以看出，韩国血友病患者的CD4水平降低，CD8水平升高，CD4:CD8比值降低。血友病患者对有丝分裂原、植物血凝素和刀豆球蛋白A的淋巴细胞反应减弱，自然杀伤细胞活性降低。此外，血友病患者白细胞介素-II的产生低于健康对照组。B淋巴细胞百分比显著降低，但免疫球蛋白（Ig）G的血清水平升高。然而，血清Ig A和Ig M水平正常。这项研究表明，仅接受国产凝血因子VIII浓缩剂治疗的HIV抗体阴性韩国血友病患者中，免疫异常的发生率很高。