Boosman R, Niewold T A, Mutsaers C W, Gruys E
Department of General and Large Animal Surgery, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
Am J Vet Res. 1989 Oct;50(10):1690-4.
The concentrations of serum amyloid A (SAA) in 4 cows given Escherichia coli endotoxin as an acute-phase stimulant were quantitatively evaluated by use of an indirect micro-ELISA method and compared with other clinical hematologic values. Serum amyloid A concentration changed minimally after intradermal infection of endotoxin. The concentration of SAA was increased 5 hours after IV injection of endotoxin, with maximal concentration after 17 to 20 hours. The increase in SAA concentration coincided with decreasing serum Zn and Fe concentrations; however, with decreasing serum Zn and Fe concentrations; however, Zn and Fe concentrations appeared to be restored when SAA concentration was still maximal. It was concluded that the SAA response of cattle is comparable with that of other species and can be used for monitoring the activity of clinical inflammation and tissue injury.
采用间接微量酶联免疫吸附测定法对4头注射大肠杆菌内毒素作为急性期刺激物的奶牛血清淀粉样蛋白A（SAA）浓度进行定量评估，并与其他临床血液学指标进行比较。内毒素皮内感染后血清淀粉样蛋白A浓度变化极小。静脉注射内毒素5小时后SAA浓度升高，17至20小时后达到最高浓度。SAA浓度升高与血清锌和铁浓度降低同时出现；然而，当SAA浓度仍处于最高水平时，锌和铁浓度似乎已恢复。得出的结论是，牛的SAA反应与其他物种相当，可用于监测临床炎症和组织损伤的活动情况。
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