多个APOE基因变异对老年男性队列认知功能的影响——来自规范衰老研究的结果。
Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study.
作者信息
Prada Diddier, Colicino Elena, Power Melinda C, Cox David G, Weisskopf Marc G, Hou Lifang, Spiro Iii Avron, Vokonas Pantel, Zhong Jia, Sanchez-Guerra Marco, Herrera Luis A, Schwartz Joel, Baccarelli Andrea A
机构信息
Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston 02115, MA, USA.
出版信息
BMC Psychiatry. 2014 Aug 1;14:223. doi: 10.1186/s12888-014-0223-x.
BACKGROUND
APOE is the biomarker with the greatest known influence on cognitive function; however, the effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations.
METHODS
We evaluated APOE polymorphisms using multiplex PCR for genotyping and Mini-Mental State Examination (MMSE) to evaluate cognitive function in 819 individuals from VA Normative Aging Study.
RESULTS
Combinatorial analysis of all polymorphisms and individual analysis of polymorphisms rs449647, rs405509, rs440446 and rs7412 did not show any association with cognitive performance. Polymorphism rs429358 was associated with better cognitive performance (odds of MMSE ≤ 25 = 0.63, 95% CI 0.42-0.95; p = 0.03) in the oldest subsample (5th quintile of age) (odds of MMSE ≤ 25 = 0.34; 95% CI 0.13-0.86; p = 0.02). APOE allele ε4 was also associated with better cognitive performance (odds of MMSE ≤ 25 = 0.61, 95% CI 0.40-0.94; p = 0.02), also in the oldest subsample (odds of MMSE ≤ 25 = 0.35, 95% CI 0.14-0.90; p = 0.03).
CONCLUSIONS
These results suggest a beneficial effect of polymorphism rs429358 in the oldest men.
背景
载脂蛋白E（APOE）是已知对认知功能影响最大的生物标志物；然而，涉及多态性rs449647、rs405509、rs440446、rs429358和rs7412的复杂单倍型对老年人群的影响尚未得到研究。
方法
我们采用多重聚合酶链反应（PCR）进行基因分型，以评估819名参与美国退伍军人规范老化研究的个体的APOE多态性，并使用简易精神状态检查表（MMSE）评估其认知功能。
结果
所有多态性的组合分析以及多态性rs449647、rs405509、rs440446和rs7412的个体分析均未显示与认知表现存在任何关联。在年龄最大的子样本（年龄的第五分位数）中，多态性rs429358与更好的认知表现相关（MMSE≤25的比值比=0.63，95%置信区间0.42-0.95；p=0.03）（MMSE≤25的比值比=0.34；95%置信区间0.13-0.86；p=0.02）。APOE等位基因ε4也与更好的认知表现相关（MMSE≤25的比值比=0.61，95%置信区间0.40-0.94；p=0.02），同样在年龄最大的子样本中（MMSE≤25的比值比=0.35，95%置信区间0.14-0.90；p=0.03）。
结论
这些结果表明多态性rs429358对年龄最大的男性具有有益影响。
Zotero 插件