Vornicova Olga, Hershkovitz Dov, Yablonski-Peretz Tamar, Ben-Itzhak Ofer, Keidar Zohar, Bar-Sela Gil
Division of Oncology, Rambam Health Care Campus and Technion-Israel Institute of Technology, Haifa, Israel.
Institute of Pathology, Rambam Health Care Campus and Technion-Israel Institute of Technology, Haifa, Israel.
Oncologist. 2014 Sep;19(9):1006-7. doi: 10.1634/theoncologist.2014-0054. Epub 2014 Aug 1.
Extramammary Paget’s disease is a rare intraepithelial malignant condition affecting the apocrine gland-bearing skin. In this case, a genomic alteration, ERBB2 S310F mutation, was discovered. The ERBB2 S310F mutation seems to be a transforming mutation that should be targeted with anti-HER2 drugs. Genomic tests are justified in rare tumors.
乳房外佩吉特病是一种罕见的上皮内恶性疾病,累及含顶泌汗腺的皮肤。在该病例中,发现了一种基因改变,即ERBB2 S310F突变。ERBB2 S310F突变似乎是一种转化突变,应该用抗HER2药物进行靶向治疗。基因检测对于罕见肿瘤是合理的。